The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Article Details
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Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell. 2000 Dec 22;103(7):1143-54.
- PubMed ID
- 11163189 [ View in PubMed]
- Abstract
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID 30S ribosomal protein S10 Q5SHN7 Details 30S ribosomal protein S12 Q5SHN3 Details 30S ribosomal protein S11 P80376 Details 30S ribosomal protein S13 P80377 Details 30S ribosomal protein S15 Q5SJ76 Details 30S ribosomal protein S16 Q5SJH3 Details 30S ribosomal protein S18 Q5SLQ0 Details 30S ribosomal protein S19 Q5SHP2 Details 30S ribosomal protein S20 P80380 Details 30S ribosomal protein S4 P80373 Details 30S ribosomal protein S5 Q5SHQ5 Details 30S ribosomal protein S6 Q5SLP8 Details 30S ribosomal protein S7 P17291 Details 30S ribosomal protein S9 P80374 Details 30S ribosomal protein Thx Q5SIH3 Details 30S ribosomal protein S2 P80371 Details 30S ribosomal protein S3 P80372 Details 30S ribosomal protein S14 type Z P0DOY6 Details 30S ribosomal protein S17 P0DOY7 Details 30S ribosomal protein S8 P0DOY9 Details