Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
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Bergelson JM, St John N, Kawaguchi S, Chan M, Stubdal H, Modlin J, Finberg RW
Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
J Virol. 1993 Nov;67(11):6847-52.
- PubMed ID
- 8411387 [ View in PubMed]
- Abstract
Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.