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Displaying drugs 151 - 175 of 13485 in total

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized...
Approved
Investigational
Matched Iupac: … 4R)-4-[(1R,3aS,3bR,4S,5aS,7R,9aS,9bS,11aR)-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … a minor fraction of the human bile acid pool. ... [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by ... [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary …

Amlexanox

Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of...
Approved
Investigational
Withdrawn
Matched International brands: … OraDisc A …
Matched Description: … Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect ... Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. ... between 5% and 50% of the general population. …

Copanlisib

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational
Matched Description: … [A261730] Copanlisib was granted accelerated approval by the FDA in September 2017 for the treatment ... PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth ... against the alpha and delta isoforms. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Ertapenem

Ertapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics. It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to...
Approved
Investigational
Matched Description: … [L14339] It was first authorized for use in the US in November 2001 and in Europe in April 2002. ... Ertapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics. ... [A447] Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic …
Matched Products: … ERTAPENEM 1G/VIAL POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …

Almotriptan

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that...
Approved
Investigational
Matched Description: … Almotriptan is in a class of medications called selective serotonin receptor agonists. ... Almotriptan is a triptan drug for the treatment of migraine headaches. ... It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, …
Matched Categories: … Monoamine Oxidase A Substrates …

Estetrol

Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. It is more potent and...
Approved
Investigational
Matched Iupac: … (1R,2R,3R,3aS,3bR,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene …
Matched Description: … product in the world. ... Estetrol is the first new estrogen introduced to the USA in over 50 years and is the first approved estetrol ... The combination of drospirenone and estetrol offers a new choice with a favourable safety profile for …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Carmustine

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985)....
Approved
Investigational
Matched Description: … It is used in the treatment of brain tumors and various other malignant neoplasms. ... to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). ... A cell-cycle phase nonspecific alkylating antineoplastic agent. …
Matched Products: … STINARED® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE ... CARMUSTINA 100 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... BiCNU-100MG (CARMUSTINE FOR INJECTION USP 100MG) & DEHYDRATED ALCOHOL INJECTION USP AS A COMBIPACK …

Amoxapine

Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation....
Approved
Matched Description: … Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative ... In depressed individuals, amoxapine exerts a positive effect on mood. ... They contain a tricyclic ring system with an alkyl amine substituent on the central ring. …
Matched Categories: … Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Ergocalciferol

Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the...
Approved
Nutraceutical
Matched Description: … ] by the presence of a double bond between C22 and C23 and the presence of a methyl group at C24. ... Ergocalciferol was isolated for the first time from yeast in 1931 and its structure was elucidated in ... [A177526] It is synthesized by some plants in the presence of UVB light. …
Matched Mixtures name: … One A Day Tab ... Aquasol A & D Drops ... Complete One A Day Tab …

Rosuvastatin

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Description: … of death in high-income countries and a major cause of morbidity around the world. ... third step in a sequence of metabolic reactions involved in the production of several compounds involved ... clinical studies to result in a 45.8% to 54.6% decreases in LDL cholesterol levels, which is about three-fold …
Matched Categories: … Drugs Used in Diabetes …
Matched Products: … ROSUVASTATIN 1 A 5MG ... ROSUVASTATIN 1 A 10MG ... ROSUVASTATIN 1 A 20MG …

Ioxaglic acid

Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during...
Approved
Investigational
Matched Description: … Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray ... film, improving the visualization of important structures and organs during angiography, arteriography ... This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Daptomycin

Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked...
Approved
Investigational
Matched Description: … [A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil ... Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive ... samples from Mount Ararat in Turkey. …
Matched Products: … Daptomycin in Sodium Chloride ... CUBICIN® 350 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE …

Larotrectinib

Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Iupac: … (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine …
Matched Description: … kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important ... both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress ... [L49821] Larotrectinib was granted accelerated approval by the FDA in November 2018 for the treatment …

Gadobutrol

Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to other GBCA and thus requires a lesser...
Approved
Matched Description: … due to the dissociation of gadolinium from the chelates, although gadobutrol tends to have a lower risk ... agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. ... compared to other GBCA and thus requires a lesser injection volume. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Gadograf 1,0 mmol/ml Injektionslösung in Fertigspritzen ... Gadovist 1,0 mmol/ml Injektionslösung in Fertigspritzen/Patronen …

Heparin

Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular ... higher risk of bleeding and higher risk of osteoporosis in long term use. ... It is a naturally occurring anticoagulant released from mast cells. …
Matched Mixtures name: … Heparin Sodium in Dextrose ... Heparin Sodium in Dextrose ... Heparin Sodium in Dextrose …
Matched Products: … Heparin Sodium in Dextrose ... Heparin Sodium in Sodium Chloride ... Heparin Sodium In Sodium Chloride …

Bendamustine

Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine...
Approved
Investigational
Matched Description: … Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia ... Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups ... alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index …
Matched Products: … GENSTINA® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …

Ginkgo biloba

Ginkgo biloba extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of ginkgo biloba use the standardized extract of Ginkgo biloba (EGb) 761 (EGb761), which...
Approved
Investigational
Nutraceutical
Matched Description: … the World Health Organization. ... _Ginkgo biloba_ is found in a number of homeopathic and over-the-counter herbal products and dietary ... of _Ginkgo biloba_ (EGb) 761 (EGb761), which was developed by a German pharmaceutical company in 1964 …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Products: … EXTRACTO DE GINKO BILOBA AL 24 % EQUIVALENTE A 9.6 MG DE GLICOSIDOS FLAVONOIDES. …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Description: … leading cause of death in high-income countries and a major cause of morbidity around the world. ... third step in a sequence of metabolic reactions involved in the production of several compounds involved ... in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin …

Hydrocortisone acetate

Approved
Vet approved
Matched Iupac: … 1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Mixtures name: … Alcortin A ... Alcortin A …
Matched Products: … Poli-A …

Abemaciclib

Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for...
Approved
Investigational
Matched Description: … the cell cycle and promotion of cancer cell growth in case of unregulated activity. ... Abemaciclib has been used in trials studying the treatment of melanoma, lymphoma, neoplasm, solid tumor ... It is either given alone in patients who has undergone endocrine therapy and chemotherapy after the metastasis …
Matched Categories: … MATE 1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Fentanyl

Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like morphine and oxycodone. Fentanyl's high potency has also...
Approved
Illicit
Investigational
Vet approved
Matched Description: … Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia ... [A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose ... Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. …
Matched Products: … DUROGESIC SMAT 12 A 2.1MG ... DUROGESIC SMAT 25 A 4.2MG ... DUROGESIC SMAT 50 A 8.4MG …

Dihydro-alpha-ergocryptine

Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine. Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product...
Approved
Matched Description: … These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. …

Ensulizole

Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly...
Approved
Matched Description: … According to the FDA, the maximal approved concentration of ensulizole is 148 mM although concentrations ... It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter ... compounds due to its minimal protection against UV-A wavelengths. …
Matched Mixtures name: … Queens Rose Whole In One Sunblock ... Aqua Fusion SPF 15 Peau Normale A Seche ... Happyderm SPF 15 Peaux Normales A Seches …
Matched Products: … Covergirl Outlast All Day Stay Fabulous 3-IN-1 Foundation ... Dolce and Gabbana The Foundation Perfect Matte Broadspectrum SPF 20 All shades …

Peginterferon beta-1a

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system ... occur more frequently in women than in men. ... [L5801] MS is one of the most common causes of neurological disability in young adults and is found to …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Niacin

Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]
Approved
Investigational
Nutraceutical
Matched Description: … , and to reduce the risk of myocardial infarctions. ... Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia …
Matched Mixtures name: … Extra Once A Day ... Once A Day Tablets ... Maximum Once A Day …
Displaying drugs 151 - 175 of 13485 in total