Febuxostat hemihydrateProduct ingredient for Febuxostat
- Name
- Febuxostat hemihydrate
- Drug Entry
- Febuxostat
Febuxostat is a non-purine xanthine oxidase (XO) inhibitor.4 In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout.5 In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout who have an inadequate response or intolerance to allopurinol.10 Gout is a form of arthritis that is caused by the accumulation of uric acid crystal in or around a joint, leading to inflammation and further deposition of uric acid crystal deposition in bones, joints, tissues, and other organs in the long term. Gout is closely associated with hyperuricemia. Febuxostat works by inhibiting the activity of an enzyme that is responsible for the synthesis of uric acid, thereby reducing serum uric acid levels.5
In February 2019, a black box warning for febuxostat was added, based on the findings of a post-market clinical study (the CARES trial) where there was an increased risk of cardiovascular (CV) fatal outcomes in patients with gout and known cardiovascular disease treated with febuxostat, when compared to those treated with allopurinol. The manufacturer and the FDA advise health professionals to limit the use of febuxostat to second-line therapy in patients who have inadequate response or intolerance to allopurinol, and to avoid the use of febuxostat in patients with cardiovascular diseases.1,9
- Accession Number
- DBSALT003209
- Structure
- Synonyms
- Not Available
- UNII
- 7KC4X53ED3
- CAS Number
- 442664-09-7
- Weight
- Average: 650.77
Monoisotopic: 650.186891799 - Chemical Formula
- C32H34N4O7S2
- InChI Key
- PBDGWWSMDHCTAJ-UHFFFAOYSA-N
- InChI
- InChI=1S/2C16H16N2O3S.H2O/c2*1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20;/h2*4-6,9H,8H2,1-3H3,(H,19,20);1H2
- IUPAC Name
- bis(2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid) hydrate
- SMILES
- O.CC(C)COC1=C(C=C(C=C1)C1=NC(C)=C(S1)C(O)=O)C#N.CC(C)COC1=C(C=C(C=C1)C1=NC(C)=C(S1)C(O)=O)C#N
- External Links
- ChemSpider
- 72391605
- Predicted Properties
Property Value Source Water Solubility 0.0183 mg/mL ALOGPS logP 3.8 ALOGPS logP 3.52 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 3.08 Chemaxon pKa (Strongest Basic) 0.39 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 83.21 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 93.93 m3·mol-1 Chemaxon Polarizability 33.9 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon