Methotrimeprazine hydrochlorideProduct ingredient for Methotrimeprazine
- Name
- Methotrimeprazine hydrochloride
- Drug Entry
- Methotrimeprazine
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
- Accession Number
- DBSALT002963
- Structure
Structure for Methotrimeprazine hydrochloride (DBSALT002963)
- Synonyms
- Levomepromazine HCl / Levomepromazine hydrochloride / Levomepromazinium chloride / Methoxy-3 (dimethylamino-3 methyl-2 propyl)-10 phenothiazine hydrochloride
- UNII
- 42BB1Y2586
- CAS Number
- 1236-99-3
- Weight
- Average: 364.93
Monoisotopic: 364.1376123 - Chemical Formula
- C19H25ClN2OS
- InChI Key
- ODLGFPIWRAEFAN-PFEQFJNWSA-N
- InChI
- InChI=1S/C19H24N2OS.ClH/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;/h5-11,14H,12-13H2,1-4H3;1H/t14-;/m1./s1
- IUPAC Name
- [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine hydrochloride
- SMILES
- Cl.COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1
- External Links
- ChemSpider
- 10128525
- ChEBI
- 31773
- ChEMBL
- CHEMBL2104973
- Predicted Properties
Property Value Source Water Solubility 0.00525 mg/mL ALOGPS logP 4.84 ALOGPS logP 4.25 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.42 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 15.71 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 99.83 m3·mol-1 Chemaxon Polarizability 36.77 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon