Remifentanil hydrochlorideProduct ingredient for Remifentanil
- Name
- Remifentanil hydrochloride
- Drug Entry
- Remifentanil
Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.
- Accession Number
- DBSALT001450
- Structure
- Synonyms
- Remifentanil HCl
- UNII
- 5V444H5WIC
- CAS Number
- 132539-07-2
- Weight
- Average: 412.91
Monoisotopic: 412.1764997 - Chemical Formula
- C20H29ClN2O5
- InChI Key
- WFBMIPUMYUHANP-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H28N2O5.ClH/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2;/h5-9H,4,10-15H2,1-3H3;1H
- IUPAC Name
- methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate hydrochloride
- SMILES
- Cl.CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC
- External Links
- ChemSpider
- 54802
- ChEBI
- 32091
- ChEMBL
- CHEMBL1201120
- Wikipedia
- Remifentanil
- Predicted Properties
Property Value Source Water Solubility 0.591 mg/mL ALOGPS logP 1.75 ALOGPS logP 1.52 Chemaxon logS -2.8 ALOGPS pKa (Strongest Basic) 7.51 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 76.15 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 100.56 m3·mol-1 Chemaxon Polarizability 40.14 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon