Pilocarpine nitrateProduct ingredient for Pilocarpine
- Name
- Pilocarpine nitrate
- Drug Entry
- Pilocarpine
A naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist.1,2 Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors.2 Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by pilocarpine dates back to 1875.3
- Accession Number
- DBSALT001181
- Structure
- Synonyms
- 2(3H)-FURANONE, 3-ETHYLDIHYDRO-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-, (3S-CIS)-, MONONITRATE
- UNII
- M20T465H6J
- CAS Number
- 148-72-1
- Weight
- Average: 271.273
Monoisotopic: 271.116820659 - Chemical Formula
- C11H17N3O5
- InChI Key
- PRZXEPJJHQYOGF-GNAZCLTHSA-N
- InChI
- InChI=1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
- IUPAC Name
- (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one; nitric acid
- SMILES
- O[N+]([O-])=O.CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O
- External Links
- ChemSpider
- 571458
- ChEMBL
- CHEMBL1213136
- Predicted Properties
Property Value Source Water Solubility 2.07 mg/mL ALOGPS logP 1.15 ALOGPS logP 0.95 Chemaxon logS -2 ALOGPS pKa (Strongest Basic) 6.61 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 44.12 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 56.53 m3·mol-1 Chemaxon Polarizability 22.31 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon