Bisoprolol fumarateProduct ingredient for Bisoprolol
- Name
- Bisoprolol fumarate
- Drug Entry
- Bisoprolol
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.4,17 It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.4 Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as Carvedilol and Labetalol. It may be used alone or in combination with other drugs to manage hypertension17 and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.13
- Accession Number
- DBSALT001015
- Structure
- Synonyms
- Bisoprolol hemifumarate
- UNII
- UR59KN573L
- CAS Number
- 104344-23-2
- Weight
- Average: 766.97
Monoisotopic: 766.461575573 - Chemical Formula
- C40H66N2O12
- InChI Key
- VMDFASMUILANOL-WXXKFALUSA-N
- InChI
- InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
- IUPAC Name
- (2E)-but-2-enedioic acid; bis(1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol)
- SMILES
- [H]\C(=C(\[H])C(O)=O)C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1
- External Links
- ChemSpider
- 4444521
- ChEBI
- 3128
- ChEMBL
- CHEMBL1472989
- Wikipedia
- Bisoprolol
- Predicted Properties
Property Value Source Water Solubility 0.0707 mg/mL ALOGPS logP 2.3 ALOGPS logP 2.2 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 14.09 Chemaxon pKa (Strongest Basic) 9.67 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 59.95 Å2 Chemaxon Rotatable Bond Count 26 Chemaxon Refractivity 92.15 m3·mol-1 Chemaxon Polarizability 38.99 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon