Tamsulosin hydrochlorideProduct ingredient for Tamsulosin
- Name
- Tamsulosin hydrochloride
- Drug Entry
- Tamsulosin
Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.Label It is indicated for the treatment of signs and symptoms of benign prostatic hypertrophy.Label Antagonism of these receptors leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, allowing for better urinary flow.Label Other alpha-1 adrenoceptor antagonists developed in the 1980s were less selective and more likely to act on the smooth muscle of blood vessels, resulting in hypotension.5
Tamsulosin was first approved by the FDA on April 15, 1997.6
- Accession Number
- DBSALT000978
- Structure
- Synonyms
- Tamsulosin HCl
- UNII
- 11SV1951MR
- CAS Number
- 106463-17-6
- Weight
- Average: 444.973
Monoisotopic: 444.148570445 - Chemical Formula
- C20H29ClN2O5S
- InChI Key
- ZZIZZTHXZRDOFM-XFULWGLBSA-N
- InChI
- InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
- IUPAC Name
- 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzene-1-sulfonamide hydrochloride
- SMILES
- Cl.[H][C@@](C)(CC1=CC(=C(OC)C=C1)S(N)(=O)=O)NCCOC1=CC=CC=C1OCC
- External Links
- Human Metabolome Database
- HMDB0042022
- ChemSpider
- 4515016
- ChEBI
- 9399
- ChEMBL
- CHEMBL1200914
- Wikipedia
- Tamsulosin
- Predicted Properties
Property Value Source Water Solubility 0.00655 mg/mL ALOGPS logP 3.05 ALOGPS logP 2.04 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 9.93 Chemaxon pKa (Strongest Basic) 9.28 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 99.88 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 108.86 m3·mol-1 Chemaxon Polarizability 43.37 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon