Verapamil hydrochlorideProduct ingredient for Verapamil
- Name
- Verapamil hydrochloride
- Drug Entry
- Verapamil
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,19 and was the first calcium channel antagonist to be introduced into therapy in the early 1960s.13 It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like diltiazem and flunarizine, but is chemically unrelated to other cardioactive medications.19 Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.5
- Accession Number
- DBSALT000534
- Structure
- Synonyms
- Verapamil HCl
- UNII
- V3888OEY5R
- CAS Number
- 152-11-4
- Weight
- Average: 491.063
Monoisotopic: 490.259835453 - Chemical Formula
- C27H39ClN2O4
- InChI Key
- DOQPXTMNIUCOSY-UHFFFAOYSA-N
- InChI
- InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
- IUPAC Name
- 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
- SMILES
- Cl.COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1
- External Links
- PubChem Compound
- 62969
- ChemSpider
- 56679
- ChEMBL
- CHEMBL1280
- Wikipedia
- Verapamil
- Predicted Properties
Property Value Source Water Solubility 0.00394 mg/mL ALOGPS logP 5.23 ALOGPS logP 5.04 Chemaxon logS -5.1 ALOGPS pKa (Strongest Basic) 9.68 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 63.95 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 132.65 m3·mol-1 Chemaxon Polarizability 52.66 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon