Ethambutol hydrochlorideProduct ingredient for Ethambutol
- Name
- Ethambutol hydrochloride
- Drug Entry
- Ethambutol
Ethambutol is a bacteriostatic agent indicated alongside medications such as isoniazid, rifampin, and pyrazinamide in the treatment of pulmonary tuberculosis.13 Ethambutol was first described in the literature in 1961.11 It was developed out of a need for therapies active against isoniazid resistant strains of Mycobacterium tuberculosis.11
Ethambutol was granted FDA approval on 6 November 1967.12
- Accession Number
- DBSALT000446
- Structure
- Synonyms
- Ethambutol dihydrochloride / Ethambutol HCl
- UNII
- QE4VW5FO07
- CAS Number
- 1070-11-7
- Weight
- Average: 277.232
Monoisotopic: 276.1371335 - Chemical Formula
- C10H26Cl2N2O2
- InChI Key
- AUAHHJJRFHRVPV-BZDVOYDHSA-N
- InChI
- InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
- IUPAC Name
- [(2S)-1-hydroxybutan-2-yl](2-{[(2S)-1-hydroxybutan-2-yl]azaniumyl}ethyl)azanium dichloride
- SMILES
- [Cl-].[Cl-].CC[C@@H](CO)[NH2+]CC[NH2+][C@@H](CC)CO
- External Links
- KEGG Drug
- D00878
- PubChem Compound
- 14051
- ChemSpider
- 13432
- ChEBI
- 4878
- ChEMBL
- CHEMBL3140361
- Wikipedia
- Ethambutol
- Predicted Properties
Property Value Source logP -0.059 Chemaxon pKa (Strongest Acidic) 14.82 Chemaxon pKa (Strongest Basic) 9.55 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 73.68 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 80.72 m3·mol-1 Chemaxon Polarizability 25.01 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon