Reaction: Levomilnacipran to 1 product
- Reaction
- Reaction type
- desethylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- inactive
- References
- Brunner V, Maynadier B, Chen L, Roques L, Hude I, Seguier S, Barthe L, Hermann P: Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats. Drug Des Devel Ther. 2015 Jun 23;9:3199-215. doi: 10.2147/DDDT.S80886. eCollection 2015. [Article]
- Bruno A, Morabito P, Spina E, Muscatello MR: The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review. Curr Neuropharmacol. 2016;14(2):191-9. [Article]
- FDA Approved Drug Products: FETZIMA (levomilnacipran) extended-release capsules, for oral use (August 2023) [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 2D6 Not Available Not Available implied Cytochrome P450 2J2 Not Available Not Available implied
