Reaction: Tretinoin to 1 product
- Reaction
- Reaction type
- hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
- Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. [Article]
- Marill J, Capron CC, Idres N, Chabot GG: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. doi: 10.1016/s0006-2952(01)00925-x. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 3A7 Not Available Not Available implied Cytochrome P450 4A11 Not Available Not Available implied Cytochrome P450 2B6 Not Available Not Available implied Cytochrome P450 2A6 Not Available Not Available implied Cytochrome P450 2C9 Not Available Not Available implied Cytochrome P450 2C18 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 3A5 Not Available Not Available implied