Reaction: Fluvastatin to 1 product
- Reaction
- Reaction type
- 5-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Toda T, Eliasson E, Ask B, Inotsume N, Rane A: Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32. doi: 10.1111/j.1742-7843.2009.00453.x. Epub 2009 Aug 6. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 1A1 Not Available Not Available confirmed Cytochrome P450 2C8 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed