Reaction: Gliclazide to 1 product
- Reaction
- Reaction type
- tolylmethylhydroxylation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- unknown
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Elliot DJ, Suharjono, Lewis BC, Gillam EM, Birkett DJ, Gross AS, Miners JO: Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination. Br J Clin Pharmacol. 2007 Oct;64(4):450-7. Epub 2007 May 22. [Article]
- Oida T, Yoshida K, Kagemoto A, Sekine Y, Higashijima T: The metabolism of gliclazide in man. Xenobiotica. 1985 Jan;15(1):87-96. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 2C18 Not Available Not Available confirmed