Reaction: Gliclazide to 1 product
- Reaction
- Reaction type
- 7-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Elliot DJ, Suharjono, Lewis BC, Gillam EM, Birkett DJ, Gross AS, Miners JO: Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination. Br J Clin Pharmacol. 2007 Oct;64(4):450-7. Epub 2007 May 22. [Article]
- Oida T, Yoshida K, Kagemoto A, Sekine Y, Higashijima T: The metabolism of gliclazide in man. Xenobiotica. 1985 Jan;15(1):87-96. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 2C18 Not Available Not Available confirmed Cytochrome P450 2C8 Not Available Not Available confirmed