V-type proton ATPase 21 kDa proteolipid subunit
Details
- Name
- V-type proton ATPase 21 kDa proteolipid subunit
- Synonyms
- ATP6F
- hATPL
- V-ATPase 21 kDa proteolipid subunit
- Vacuolar proton pump 21 kDa proteolipid subunit
- Gene Name
- ATP6V0B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052435|V-type proton ATPase 21 kDa proteolipid subunit MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISL SVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSA TDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVE IFGSAIGLFGVIVAILQTSRVKMGD
- Number of residues
- 205
- Molecular Weight
- 21406.09
- Theoretical pI
- Not Available
- GO Classification
- Functionsproton-transporting ATPase activity, rotational mechanism / transporter activityProcessesinsulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / proton transmembrane transport / regulation of macroautophagy / transferrin transportComponentscell / endosome membrane / integral component of membrane / phagocytic vesicle membrane / proton-transporting V-type ATPase, V0 domain / vacuolar membrane
- General Function
- Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Specific Function
- Proton-transporting atpase activity, rotational mechanism
- Pfam Domain Function
- ATP-synt_C (PF00137)
- Transmembrane Regions
- 4-24 52-72 91-111 138-158 176-196
- Cellular Location
- Vacuole membrane
- Gene sequence
>lcl|BSEQ0052436|V-type proton ATPase 21 kDa proteolipid subunit (ATP6V0B) ATGACGGGGCTAGCACTGCTCTACTCCGGGGTCTTCGTGGCCTTCTGGGCCTGCGCGCTG GCCGTGGGAGTCTGCTACACCATTTTTGATTTGGGCTTCCGCTTTGATGTGGCATGGTTC CTGACGGAGACTTCGCCCTTCATGTGGTCCAACCTGGGCATTGGCCTAGCTATCTCCCTG TCTGTGGTTGGGGCAGCCTGGGGCATCTATATTACCGGCTCCTCCATCATTGGTGGAGGA GTGAAGGCCCCCAGGATCAAGACCAAGAACCTGGTCAGCATCATCTTCTGTGAGGCTGTG GCCATCTACGGCATCATCATGGCAATTGTCATTAGCAACATGGCTGAGCCTTTCAGTGCC ACAGACCCCAAGGCCATCGGCCATCGGAACTACCATGCAGGCTACTCCATGTTTGGGGCT GGCCTCACCGTAGGCCTGTCTAACCTCTTCTGTGGAGTCTGCGTGGGCATCGTGGGCAGT GGGGCTGCCCTGGCCGATGCTCAGAACCCCAGCCTCTTTGTAAAGATTCTCATCGTGGAG ATCTTTGGCAGCGCCATTGGCCTCTTTGGGGTCATCGTCGCAATTCTTCAGACCTCCAGA GTGAAGATGGGTGACTAG
- Chromosome Location
- 1
- Locus
- 1p34.1
- External Identifiers
Resource Link UniProtKB ID Q99437 UniProtKB Entry Name VATO_HUMAN HGNC ID HGNC:861 - General References
- Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J: Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F). Genomics. 1998 Jun 1;50(2):222-8. doi: 10.1006/geno.1998.5310. [Article]
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