V-type proton ATPase 116 kDa subunit a isoform 1
Details
- Name
- V-type proton ATPase 116 kDa subunit a isoform 1
- Synonyms
- ATP6N1
- ATP6N1A
- Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
- V-ATPase 116 kDa isoform a1
- Vacuolar adenosine triphosphatase subunit Ac116
- Vacuolar proton pump subunit 1
- Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
- VPP1
- Gene Name
- ATP6V0A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052437|V-type proton ATPase 116 kDa subunit a isoform 1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEE MDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKR NFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERI PTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGF RASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM KAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQT PPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFA VWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWS VRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMS VILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAH TSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRR QYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQ AIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFT AFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE
- Number of residues
- 837
- Molecular Weight
- 96411.91
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATPase binding / proton-transporting ATPase activity, rotational mechanismProcessesinsulin receptor signaling pathway / ion transmembrane transport / neutrophil degranulation / phagosome acidification / regulation of macroautophagy / toxin transport / transferrin transport / vacuolar acidificationComponentscell / cytosol / endosome membrane / extracellular exosome / ficolin-1-rich granule membrane / Golgi apparatus / integral component of membrane / intracellular membrane-bounded organelle / lysosomal membrane / melanosome / nuclear speck / perinuclear region of cytoplasm / phagocytic vesicle membrane / plasma membrane / secretory granule membrane / vacuolar proton-transporting V-type ATPase complex / vacuolar proton-transporting V-type ATPase, V0 domain
- General Function
- Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).
- Specific Function
- Atpase binding
- Pfam Domain Function
- V_ATPase_I (PF01496)
- Transmembrane Regions
- 389-407 410-426 442-471 535-554 573-593 639-658 725-749 771-809
- Cellular Location
- Cytoplasmic vesicle membrane
- Gene sequence
>lcl|BSEQ0052438|V-type proton ATPase 116 kDa subunit a isoform 1 (ATP6V0A1) ATGGGGGAGCTTTTCCGGAGTGAAGAAATGACACTGGCCCAGCTTTTTCTACAGTCAGAG GCTGCTTATTGTTGTGTCAGTGAATTAGGAGAACTTGGAAAGGTTCAGTTTCGTGACTTA AATCCAGATGTGAATGTTTTCCAACGGAAATTTGTGAATGAAGTTAGAAGATGTGAAGAA ATGGATCGAAAGCTTCGATTTGTTGAGAAAGAGATAAGAAAAGCTAACATTCCGATTATG GACACCGGTGAAAACCCAGAGGTTCCCTTCCCCCGGGACATGATTGACTTAGAGGCCAAT TTTGAGAAGATTGAAAATGAACTGAAGGAAATCAACACAAACCAGGAAGCTCTGAAGAGA AACTTCCTGGAACTGACCGAATTAAAATTTATACTTCGCAAAACTCAGCAATTTTTTGAT GAGATGGCGGATCCAGACTTGTTGGAAGAGTCCTCATCCCTCTTGGAGCCAAGTGAGATG GGAAGAGGCACTCCTTTAAGACTTGGCTTCGTGGCTGGTGTCATTAACCGGGAGCGCATC CCTACTTTTGAGCGCATGCTTTGGCGGGTATGCCGGGGAAATGTGTTCCTGCGACAGGCT GAAATCGAGAACCCCCTGGAGGATCCTGTGACTGGCGACTACGTGCACAAGTCTGTGTTT ATCATTTTCTTCCAAGGCGATCAGCTGAAAAACAGAGTCAAGAAAATCTGTGAAGGGTTC CGAGCCTCACTCTATCCCTGTCCTGAGACACCACAGGAGAGGAAGGAAATGGCTTCTGGA GTGAATACCAGGATTGATGATCTCCAAATGGTTCTGAATCAAACGGAGGATCACCGCCAG AGGGTTCTGCAGGCAGCTGCTAAGAACATCCGTGTCTGGTTCATCAAAGTGCGGAAGATG AAGGCCATCTATCACACCCTGAACCTGTGCAACATAGATGTGACTCAGAAATGCTTGATT GCAGAGGTCTGGTGCCCTGTCACCGACCTTGACTCCATCCAGTTTGCACTCAGAAGGGGC ACGGAACACAGTGGTTCCACTGTACCTTCCATTTTGAACAGGATGCAGACAAACCAGACT CCCCCAACCTATAACAAAACCAACAAGTTTACCTATGGCTTTCAGAACATAGTAGATGCT TATGGAATTGGAACTTACCGAGAGATAAATCCAGCTCCGTATACTATTATCACGTTCCCT TTTCTATTTGCTGTGATGTTTGGAGACTTCGGTCATGGCATTTTAATGACCCTTTTTGCT GTGTGGATGGTACTGAGGGAGAGCCGGATCCTTTCCCAGAAGAATGAGAATGAGATGTTT AGCACTGTGTTCAGTGGTCGATACATTATTTTATTGATGGGTGTGTTCTCCATGTACACT GGCCTCATCTACAATGATTGCTTTTCCAAGTCTCTTAATATCTTTGGGTCATCCTGGAGT GTACGGCCGATGTTTACTTATAATTGGACTGAAGAGACGCTTCGGGGGAACCCTGTTCTA CAGCTGAACCCAGCCCTCCCTGGAGTGTTTGGTGGACCATACCCTTTTGGCATTGATCCA ATTTGGAACATTGCTACCAATAAACTGACGTTCTTGAACTCCTTTAAGATGAAGATGTCT GTTATCCTTGGTATCATCCATATGCTGTTTGGAGTCAGCCTGAGTCTGTTCAACCATATC TATTTCAAGAAGCCCCTGAATATCTACTTTGGATTTATTCCTGAAATAATCTTCATGACC TCTTTGTTTGGCTATTTGGTTATCCTTATTTTTTACAAGTGGACGGCCTATGATGCTCAT ACCTCTGAGAATGCACCAAGCCTTCTGATCCATTTCATAAACATGTTCCTCTTTTCCTAC CCAGAGTCTGGTTATTCAATGTTGTATTCTGGACAGAAAGGAATTCAGTGTTTCCTGGTA GTGGTTGCACTACTGTGTGTACCTTGGATGCTGCTGTTTAAACCATTGGTCCTTCGCCGT CAGTATTTGAGGAGAAAGCATTTGGGAACTCTCAACTTTGGTGGGATCAGGGTGGGCAAC GGACCGACAGAGGAGGATGCTGAGATTATTCAGCATGACCAGCTCTCCACCCACTCAGAG GACGCAGACGAGCCTTCCGAGGACGAAGTGTTTGACTTTGGGGACACCATGGTCCACCAG GCCATCCACACCATCGAGTACTGCCTGGGCTGCATCTCCAACACTGCCTCCTACTTGCGG CTCTGGGCCCTCAGCCTCGCTCATGCGCAGCTGTCTGAGGTGCTTTGGACCATGGTGATC CACATCGGCCTGAGCGTGAAGAGCTTGGCGGGAGGTTTGGTGCTGTTCTTCTTCTTCACT GCCTTTGCCACCCTGACCGTGGCCATCCTCCTGATCATGGAGGGCCTCTCGGCCTTTCTC CACGCACTGCGCTTACACTGGGTTGAGTTCCAGAATAAATTCTACAGCGGGACCGGTTTC AAGTTCTTACCCTTCTCCTTCGAGCATATTCGGGAAGGGAAGTTTGAAGAGTGA
- Chromosome Location
- 17
- Locus
- 17q21.2
- External Identifiers
Resource Link UniProtKB ID Q93050 UniProtKB Entry Name VPP1_HUMAN HGNC ID HGNC:865 - General References
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