Organic solute transporter subunit alpha
Details
- Name
- Organic solute transporter subunit alpha
- Synonyms
- OST-alpha
- OSTA
- Solute carrier family 51 subunit alpha
- Gene Name
- SLC51A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017180|Organic solute transporter subunit alpha MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLL ALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTIT SFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLL MLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTALWINTFLGVSTLLALWTLGIIS RQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCH LLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA
- Number of residues
- 340
- Molecular Weight
- 37734.575
- Theoretical pI
- 8.63
- GO Classification
- Functionsprotein heterodimerization activity / protein homodimerization activity / transporter activityProcessesbile acid and bile salt transport / transportComponentsendoplasmic reticulum membrane / integral component of membrane / plasma membrane / protein complex
- General Function
- Transporter activity
- Specific Function
- Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
- Pfam Domain Function
- Solute_trans_a (PF03619)
- Transmembrane Regions
- 49-69 88-108 119-139 182-202 219-239 256-276 295-317
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017181|Organic solute transporter subunit alpha (SLC51A) ATGGAGCCGGGCAGGACCCAGATAAAGCTTGACCCCAGGTACACAGCAGATCTTCTGGAG GTGCTGAAGACCAATTACGGCATCCCCTCCGCCTGCTTCTCTCAGCCTCCCACAGCAGCC CAACTCCTGAGAGCCCTGGGCCCTGTGGAACTTGCCCTCACTAGCATCCTGACCTTGCTG GCGCTGGGCTCCATTGCCATCTTCCTGGAGGATGCCGTCTACCTGTACAAGAACACCCTT TGCCCCATCAAGAGGCGGACTCTGCTCTGGAAGAGCTCGGCACCCACGGTGGTGTCTGTG CTGTGCTGCTTTGGTCTCTGGATCCCTCGTTCCCTGGTGCTGGTGGAAATGACCATCACC TCGTTTTATGCCGTGTGCTTTTACCTGCTGATGCTGGTCATGGTGGAAGGCTTTGGGGGG AAGGAGGCAGTGCTGAGGACGCTGAGGGACACCCCGATGATGGTCCACACAGGCCCCTGC TGCTGCTGCTGCCCCTGCTGTCCACGGCTGCTGCTCACCAGGAAGAAGCTTCAGCTGCTG ATGTTGGGCCCTTTCCAATACGCCTTCTTGAAGATAACGCTGACCCTGGTGGGCCTGTTT CTCGTCCCCGACGGCATCTATGACCCAGCAGACATTTCTGAGGGGAGCACAGCTCTATGG ATCAACACTTTCCTTGGCGTGTCCACACTGCTGGCTCTCTGGACCCTGGGCATCATTTCC CGTCAAGCCAGGCTACACCTGGGTGAGCAGAACATGGGAGCCAAATTTGCTCTGTTCCAG GTTCTCCTCATCCTGACTGCCCTACAGCCCTCCATCTTCTCAGTCTTGGCCAACGGTGGG CAGATTGCTTGTTCGCCTCCCTATTCCTCTAAAACCAGGTCTCAAGTGATGAATTGCCAC CTCCTCATACTGGAGACTTTTCTAATGACTGTGCTGACACGAATGTACTACCGAAGGAAA GACCACAAGGTTGGGTATGAAACTTTCTCTTCTCCAGACCTGGACTTGAACCTCAAAGCC TAA
- Chromosome Location
- 3
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q86UW1 UniProtKB Entry Name OSTA_HUMAN GenBank Protein ID 30348899 GenBank Gene ID AY194243 HGNC ID HGNC:29955 - General References
- Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N: OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9. [Article]
- Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA: The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G476-85. Epub 2005 Nov 3. [Article]
- Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA: FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res. 2006 Jan;47(1):201-14. Epub 2005 Oct 26. [Article]