Antitumor antibiotic C-1027 apoprotein
Details
- Name
- Antitumor antibiotic C-1027 apoprotein
- Synonyms
- C-1027-AG
- Gene Name
- cagA
- Organism
- Streptomyces globisporus
- Amino acid sequence
>lcl|BSEQ0011437|Antitumor antibiotic C-1027 apoprotein MSLRHMSRRASRFGVVAVASIGLAAAAQSVAFAAPAFSVSPASGLSDGQSVSVSVSGAAA GETYYIAQCAPVGGQDACNPATATSFTTDASGAASFSFVVRKSYTGSTPEGTPVGSVDCA TAACNLGAGNSGLDLGHVALTFG
- Number of residues
- 143
- Molecular Weight
- 13873.23
- Theoretical pI
- 6.48
- GO Classification
- FunctionsDNA bindingProcessesdefense response to bacterium
- General Function
- Dna binding
- Specific Function
- Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
- Pfam Domain Function
- Neocarzinostat (PF00960)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003949|432 bp ATGTCGTTACGTCACATGTCCCGCCGTGCTTCCAGGTTCGGCGTCGTGGCCGTCGCATCC ATCGGCCTGGCCGCCGCCGCACAGTCCGTCGCCTTCGCCGCGCCCGCCTTCTCCGTCAGT CCCGCCTCGGGTCTGAGTGACGGACAGAGCGTGTCGGTGTCGGTCAGCGGTGCCGCCGCC GGCGAGACCTACTACATCGCCCAGTGCGCTCCGGTCGGTGGCCAGGACGCGTGCAACCCG GCGACCGCGACGTCCTTCACCACGGACGCGTCCGGAGCGGCGTCGTTCAGCTTCGTCGTG CGCAAGTCGTACACGGGCTCCACGCCCGAAGGCACGCCGGTCGGCAGCGTCGACTGCGCC ACGGCCGCCTGTAACCTCGGCGCCGGCAACTCCGGGCTCGACCTCGGCCACGTGGCTCTG ACCTTCGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q06110 UniProtKB Entry Name CAGA_STRGL GenBank Protein ID 217003 GenBank Gene ID D10827 - General References
- Sakata N, Ikeno S, Hori M, Hamada M, Otani T: Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene. Biosci Biotechnol Biochem. 1992 Oct;56(10):1592-5. [Article]
- Otani T, Yasuhara T, Minami Y, Shimazu T, Zhang R, Xie MY: Purification and primary structure of C-1027-AG, a selective antagonist of antitumor antibiotic C-1027, from Streptomyces globisporus. Agric Biol Chem. 1991 Feb;55(2):407-17. [Article]
- Sugiura Y, Matsumoto T: Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore. Biochemistry. 1993 Jun 1;32(21):5548-53. [Article]