Cytochrome P450 130

Details

Name
Cytochrome P450 130
Synonyms
  • 1.14.-.-
Gene Name
cyp130
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051233|Cytochrome P450 130
MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAAR
DHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTV
RKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVD
GATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTM
VTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRD
VTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAA
RMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS
Number of residues
405
Molecular Weight
44580.16
Theoretical pI
Not Available
GO Classification
Functions
heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Components
cell wall
General Function
Not Available
Specific Function
Heme binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051234|Cytochrome P450 130 (cyp130)
ATGACATCAGTAATGTCTCACGAATTCCAGCTCGCCACCGCCGAAACCTGGCCGAATCCG
TGGCCGATGTACCGCGCGTTGCGCGACCACGACCCGGTGCACCACGTCGTCCCGCCGCAG
CGTCCCGAGTACGACTACTACGTGCTGTCCCGGCACGCCGACGTCTGGTCGGCAGCGCGG
GACCATCAGACGTTCTCGTCGGCGCAAGGCTTGACCGTTAACTACGGCGAGCTGGAAATG
ATTGGACTGCACGACACCCCGCCCATGGTGATGCAGGATCCGCCGGTCCACACCGAGTTT
CGCAAGCTGGTGTCGCGCGGCTTCACGCCACGACAGGTCGAAACCGTCGAGCCCACGGTG
CGCAAGTTCGTCGTTGAGCGGCTCGAAAAGCTGCGCGCCAACGGTGGCGGCGACATTGTC
ACCGAACTATTCAAACCGCTCCCGTCGATGGTGGTGGCGCACTATCTCGGTGTTCCCGAA
GAGGATTGGACGCAATTCGACGGGTGGACCCAGGCCATCGTGGCGGCGAACGCGGTTGAC
GGCGCCACCACCGGCGCACTGGACGCGGTCGGCTCGATGATGGCCTACTTCACCGGGCTG
ATCGAGCGACGCCGCACCGAGCCCGCCGACGACGCCATCTCCCACCTGGTAGCCGCCGGG
GTCGGCGCCGACGGCGACACCGCCGGCACACTGTCCATACTGGCGTTCACGTTCACCATG
GTCACCGGCGGCAACGACACCGTCACCGGCATGCTAGGCGGTTCGATGCCGTTGCTGCAC
CGGCGGCCCGACCAGCGCCGGCTGCTGCTGGATGACCCAGAGGGCATCCCCGACGCGGTC
GAGGAGCTGCTGCGGCTCACCTCGCCGGTGCAGGGGCTGGCGCGCACAACCACGCGCGAC
GTCACGATCGGTGACACCACCATCCCGGCCGGTCGCCGGGTGCTGCTGCTGTACGGCTCG
GCCAACCGTGACGAACGCCAATACGGCCCGGACGCAGCCGAACTCGATGTCACTCGGTGC
CCGCGCAACATCTTGACCTTCAGCCACGGCGCCCACCACTGCCTGGGTGCGGCCGCGGCC
CGGATGCAATGCCGGGTGGCGCTGACCGAACTGCTGGCCCGGTGCCCGGACTTCGAGGTG
GCCGAGTCACGCATCGTGTGGTCCGGCGGCAGTTATGTCCGGCGTCCGCTGTCGGTGCCG
TTCCGAGTGACATCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WPN5
UniProtKB Entry NameCP130_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  3. Ouellet H, Podust LM, de Montellano PR: Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem. 2008 Feb 22;283(8):5069-80. Epub 2007 Dec 18. [Article]
  4. Podust LM, Ouellet H, von Kries JP, de Montellano PR: Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines. J Biol Chem. 2009 Sep 11;284(37):25211-9. doi: 10.1074/jbc.M109.017632. Epub 2009 Jul 15. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07705(S)-econazoleexperimentalunknownDetails
DB079715-AMINO-2-{4-[(4-AMINOPHENYL)SULFANYL]PHENYL}-1H-ISOINDOLE-1,3(2H)-DIONEexperimentalunknownDetails
DB079721-(3-METHYLPHENYL)-1H-BENZIMIDAZOL-5-AMINEexperimentalunknownDetails