Glutamate receptor 4
Details
- Name
- Glutamate receptor 4
- Synonyms
- AMPA-selective glutamate receptor 4
- GluA4
- GluR-4
- GluR-D
- GLUR4
- Glutamate receptor ionotropic, AMPA 4
- Gene Name
- GRIA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037088|Glutamate receptor 4 MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA NLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGV LDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD LP
- Number of residues
- 902
- Molecular Weight
- 100870.085
- Theoretical pI
- 8.32
- GO Classification
- FunctionsAMPA glutamate receptor activity / extracellular-glutamate-gated ion channel activity / ionotropic glutamate receptor activityProcessesglutamate receptor signaling pathway / ion transmembrane transport / ionotropic glutamate receptor signaling pathway / synaptic transmission / synaptic transmission, glutamatergic / transportComponentsAMPA glutamate receptor complex / cell junction / dendrite / endocytic vesicle membrane / extracellular vesicle / plasma membrane / postsynaptic membrane
- General Function
- Ionotropic glutamate receptor activity
- Specific Function
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
- Pfam Domain Function
- Transmembrane Regions
- 545-565 618-638 814-834
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016220|Glutamate receptor 4 (GRIA4) ATGAGGATTATTTCCAGACAGATTGTCTTGTTATTTTCTGGATTTTGGGGACTCGCCATG GGAGCCTTTCCGAGCAGCGTGCAAATAGGTGGTCTCTTCATCCGAAACACAGATCAGGAA TACACTGCTTTTCGATTAGCAATTTTTCTTCATAACACCAGCCCCAATGCGTCGGAAGCT CCTTTTAATTTGGTACCTCATGTGGACAACATTGAGACAGCCAACAGTTTTGCTGTAACA AACGCCTTCTGTTCCCAGTATTCTAGAGGAGTATTTGCCATTTTTGGACTCTATGATAAG AGGTCGGTACATACCTTGACCTCATTCTGCAGCGCCTTACATATCTCCCTCATCACACCA AGTTTCCCTACTGAGGGGGAGAGCCAGTTTGTGCTGCAACTAAGACCTTCGTTACGAGGA GCACTCTTGAGTTTGCTGGATCACTACGAATGGAACTGTTTTGTCTTCCTGTATGACACA GACAGGGGATACTCGATACTCCAAGCTATTATGGAAAAAGCAGGACAAAATGGTTGGCAT GTCAGCGCTATATGTGTGGAAAATTTTAATGATGTCAGCTATAGGCAACTTCTAGAAGAA CTTGACAGAAGACAAGAGAAGAAGTTTGTAATAGACTGTGAGATAGAGAGACTTCAAAAC ATATTAGAACAGATTGTAAGTGTTGGAAAGCATGTTAAAGGCTACCATTATATCATTGCA AACTTGGGATTCAAGGATATTTCTCTTGAGAGGTTTATACATGGTGGAGCCAATGTTACT GGATTCCAGTTGGTGGATTTTAATACACCTATGGTAATCAAACTAATGGATCGCTGGAAG AAACTAGATCAGAGAGAGTATCCAGGATCTGAGACTCCTCCAAAGTACACCTCTGCTCTG ACTTATGATGGAGTCCTTGTGATGGCTGAAACTTTCCGAAGTCTTAGGAGGCAGAAAATT GATATCTCAAGGAGAGGAAATGCTGGGGATTGTCTGGCAAATCCTGCTGCTCCATGGGGC CAGGGAATTGACATGGAGAGGACACTCAAACAGGTTCGAATTCAAGGGCTGACAGGGAAT GTTCAGTTTGACCACTATGGACGTAGAGTCAATTACACAATGGATGTGTTTGAGCTGAAA AGCACAGGACCTAGAAAGGTTGGTTACTGGAATGATATGGATAAGTTAGTCTTGATTCAA GATGTACCAACTCTTGGCAATGACACAGCTGCTATTGAGAACAGAACAGTGGTTGTAACC ACAATTATGGAATCCCCATATGTTATGTACAAGAAAAATCATGAAATGTTTGAAGGAAAT GACAAGTATGAAGGATACTGTGTAGATTTGGCATCTGAAATTGCAAAACATATTGGTATC AAGTATAAAATTGCCATTGTCCCTGATGGAAAATATGGAGCAAGGGATGCAGACACAAAA ATCTGGAATGGGATGGTAGGAGAACTTGTTTATGGGAAAGCAGAGATTGCTATTGCCCCT CTGACAATCACTTTGGTACGAGAGGAGGTCATTGACTTTTCTAAGCCCTTCATGAGTTTG GGCATATCTATCATGATCAAAAAGCCTCAGAAATCCAAACCAGGAGTGTTTTCCTTCTTG GATCCTCTGGCCTATGAGATTTGGATGTGCATAGTCTTTGCCTACATTGGTGTCAGCGTG GTCTTATTCCTAGTTAGTAGATTTAGTCCATATGAGTGGCACACAGAAGAGCCAGAGGAC GGAAAGGAAGGACCCAGCGACCAGCCTCCCAATGAGTTTGGCATCTTTAACAGCCTCTGG TTTTCCCTGGGTGCTTTTATGCAGCAAGGATGTGACATTTCACCCAGATCCCTCTCAGGT CGAATTGTTGGAGGTGTTTGGTGGTTCTTTACACTCATCATTATATCATCTTATACTGCT AACCTCGCTGCTTTCCTGACGGTTGAGCGAATGGTCTCTCCCATAGAAAGTGCAGAAGAC CTGGCCAAACAAACAGAAATTGCCTATGGAACACTGGATTCAGGATCAACAAAAGAATTC TTCAGAAGATCAAAAATAGCAGTGTATGAAAAGATGTGGACCTACATGCGATCAGCAGAG CCATCAGTATTCACTAGGACTACAGCTGAGGGAGTAGCTCGTGTCCGCAAATCCAAGGGC AAATTTGCCTTTCTCCTGGAGTCCACTATGAATGAATACATTGAGCAGCGAAAGCCATGT GACACGATGAAAGTGGGAGGAAATCTGGATTCCAAAGGCTATGGAGTAGCAACGCCCAAG GGTTCCTCATTAGGAACTCCTGTAAACCTTGCCGTTTTGAAACTCAGTGAGGCAGGCGTC TTAGACAAGCTGAAAAACAAATGGTGGTACGATAAAGGTGAATGTGGACCCAAGGACTCT GGAAGCAAGGACAAGACGAGTGCCTTGAGCCTGAGCAATGTAGCAGGCGTCTTCTACATT CTGGTTGGCGGCTTGGGCTTGGCAATGCTGGTGGCTTTGATAGAGTTCTGTTACAAGTCC AGGGCAGAAGCGAAGAGAATGAAGCTGACCTTTTCTGAAGCCATAAGAAACAAAGCCAGA TTATCCATCACTGGGAGTGTGGGAGAGAATGGCCGCGTCTTGACGCCTGACTGCCCAAAG GCTGTACACACTGGAACTGCAATCAGACAAAGTTCAGGATTGGCTGTCATTGCATCGGAC CTACCATAA
- Chromosome Location
- 11
- Locus
- 11q22
- External Identifiers
Resource Link UniProtKB ID P48058 UniProtKB Entry Name GRIA4_HUMAN GenBank Protein ID 790538 GenBank Gene ID U16129 GenAtlas ID GRIA4 HGNC ID HGNC:4574 - General References
- Fletcher EJ, Nutt SL, Hoo KH, Elliott CE, Korczak B, McWhinnie EA, Kamboj RK: Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4. Receptors Channels. 1995;3(1):21-31. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 2010 Dec 22;68(6):1082-96. doi: 10.1016/j.neuron.2010.11.026. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00142 Glutamic acid approved, nutraceutical unknown Details DB04982 Talampanel investigational unknown Details DB05047 CX-717 illicit, investigational unknown Details DB00898 Ethanol approved unknown Details DB13146 Fluciclovine (18F) approved no inhibitor Details DB00237 Butabarbital approved, illicit unknown antagonist Details