5-hydroxytryptamine receptor 3A
Details
- Name
- 5-hydroxytryptamine receptor 3A
- Synonyms
- 5-HT-3
- 5-HT3-A
- 5-HT3R
- 5-hydroxytryptamine receptor 3
- 5HT3R
- HTR3
- Serotonin receptor 3A
- Serotonin-gated ion channel receptor
- Gene Name
- HTR3A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000619|5-hydroxytryptamine receptor 3A MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
- Number of residues
- 478
- Molecular Weight
- 55279.835
- Theoretical pI
- 7.43
- GO Classification
- Functionsreceptor activity / serotonin binding / serotonin receptor activity / serotonin-activated cation-selective channel activity / voltage-gated potassium channel activityProcessescation transmembrane transport / cellular response to growth factor stimulus / digestion / ion transmembrane transport / neurological system process / regulation of membrane potential / response to cocaine / response to ethanol / serotonin receptor signaling pathway / synaptic transmission / transmembrane transport / transportComponentsaxon / cell junction / cytoplasm / integral component of plasma membrane / neuron projection / neuronal cell body / plasma membrane / postsynaptic membrane / synapse
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- Pfam Domain Function
- Transmembrane Regions
- 242-268 274-292 303-321 456-475
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0010242|5-hydroxytryptamine receptor 3A (HTR3A) ATGCTTGGAAAGCTCGCTATGCTGCTGTGGGTCCAGCAGGCGCTGCTCGCCTTGCTCCTC CCCACACTCCTGGCACAGGGAGAAGCCAGGAGGAGCCGAAACACCACCAGGCCCGCTCTG CTGAGGCTGTCGGATTACCTTTTGACCAACTACAGGAAGGGTGTGCGCCCCGTGAGGGAC TGGAGGAAGCCAACCACCGTATCCATTGACGTCATTGTCTATGCCATCCTCAACGTGGAT GAGAAGAATCAGGTGCTGACCACCTACATCTGGTACCGGCAGTACTGGACTGATGAGTTT CTCCAGTGGAACCCTGAGGACTTTGACAACATCACCAAGTTGTCCATCCCCACGGACAGC ATCTGGGTCCCGGACATTCTCATCAATGAGTTCGTGGATGTGGGGAAGTCTCCAAATATC CCGTACGTGTATATTCGGCATCAAGGCGAAGTTCAGAACTACAAGCCCCTTCAGGTGGTG ACTGCCTGTAGCCTCGACATCTACAACTTCCCCTTCGATGTCCAGAACTGCTCGCTGACC TTCACCAGTTGGCTGCACACCATCCAGGACATCAACATCTCTTTGTGGCGCTTGCCAGAA AAGGTGAAATCCGACAGGAGTGTCTTCATGAACCAGGGAGAGTGGGAGTTGCTGGGGGTG CTGCCCTACTTTCGGGAGTTCAGCATGGAAAGCAGTAACTACTATGCAGAAATGAAGTTC TATGTGGTCATCCGCCGGCGGCCCCTCTTCTATGTGGTCAGCCTGCTACTGCCCAGCATC TTCCTCATGGTCATGGACATCGTGGGCTTCTACCTGCCCCCCAACAGTGGCGAGAGGGTC TCTTTCAAGATTACACTCCTCCTGGGCTACTCGGTCTTCCTGATCATCGTTTCTGACACG CTGCCGGCCACTGCCATCGGCACTCCTCTCATTGGTGTCTACTTTGTGGTGTGCATGGCT CTGCTGGTGATAAGTTTGGCCGAGACCATCTTCATTGTGCGGCTGGTGCACAAGCAAGAC CTGCAGCAGCCCGTGCCTGCTTGGCTGCGTCACCTGGTTCTGGAGAGAATCGCCTGGCTA CTTTGCCTGAGGGAGCAGTCAACTTCCCAGAGGCCCCCAGCCACCTCCCAAGCCACCAAG ACTGATGACTGCTCAGCCATGGGAAACCACTGCAGCCACATGGGAGGACCCCAGGACTTC GAGAAGAGCCCGAGGGACAGATGTAGCCCTCCCCCACCACCTCGGGAGGCCTCGCTGGCG GTGTGTGGGCTGCTGCAGGAGCTGTCCTCCATCCGGCAATTCCTGGAAAAGCGGGATGAG ATCCGAGAGGTGGCCCGAGACTGGCTGCGCGTGGGCTCCGTGCTGGACAAGCTGCTATTC CACATTTACCTGCTAGCGGTGCTGGCCTACAGCATCACCCTGGTTATGCTCTGGTCCATC TGGCAGTACGCTTGA
- Chromosome Location
- 11
- Locus
- 11q23.1
- External Identifiers
Resource Link UniProtKB ID P46098 UniProtKB Entry Name 5HT3A_HUMAN GenBank Protein ID 681914 GenBank Gene ID D49394 GenAtlas ID HTR3A HGNC ID HGNC:5297 - General References
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- Bruss M, Gothert M, Hayer M, Bonisch H: Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs. Ann N Y Acad Sci. 1998 Dec 15;861:234-5. [Article]
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- Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF: The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63. [Article]
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- Cheng A, McDonald NA, Connolly CN: Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3. J Biol Chem. 2005 Jun 10;280(23):22502-7. Epub 2005 Apr 4. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00377 Palonosetron approved, investigational yes antagonist Details DB00757 Dolasetron approved, investigational yes antagonist Details DB00889 Granisetron approved, investigational yes antagonist Details DB00904 Ondansetron approved, withdrawn yes antagonist Details DB00969 Alosetron approved, withdrawn yes antagonist Details DB00721 Procaine approved, investigational, vet_approved yes antagonist Details DB00604 Cisapride approved, investigational, withdrawn yes agonist Details DB01199 Tubocurarine approved yes antagonist Details DB04885 Cilansetron investigational unknown Details DB04917 Renzapride investigational unknown Details DB05049 DDP733 investigational unknown Details DB05642 DDP-225 investigational unknown Details DB06422 Ticalopride investigational unknown Details DB00363 Clozapine approved unknown antagonist Details DB01238 Aripiprazole approved, investigational unknown antagonist Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB01224 Quetiapine approved unknown ligand Details DB00728 Rocuronium approved unknown antagonist Details DB01043 Memantine approved, investigational unknown antagonist Details DB00408 Loxapine approved unknown binder Details DB00543 Amoxapine approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00333 Methadone approved unknown antagonist Details DB01233 Metoclopramide approved, investigational yes antagonist Details DB00898 Ethanol approved unknown Details DB09068 Vortioxetine approved, investigational yes antagonist Details DB11699 Tropisetron approved, investigational yes antagonist Details DB09290 Ramosetron investigational unknown antagonist Details DB00988 Dopamine approved unknown Details DB08839 Serotonin investigational, nutraceutical unknown Details DB00555 Lamotrigine approved, investigational unknown inhibitor Details DB01221 Ketamine approved, vet_approved yes potentiator Details DB09061 Cannabidiol approved, investigational unknown antagonist Details DB14185 Aripiprazole lauroxil approved, investigational unknown Details DB01156 Bupropion approved unknown negative modulator Details DB13025 Tiapride investigational yes antagonist Details DB09304 Setiptiline experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB12141 Gilteritinib approved, investigational no inhibitor Details DB00715 Paroxetine approved, investigational unknown Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn yes inhibitor Details DB00246 Ziprasidone approved unknown antagonist Details