L-carnitine CoA-transferase
Details
- Name
- L-carnitine CoA-transferase
- Synonyms
- 2.8.3.21
- Crotonobetainyl-CoA:carnitine CoA-transferase
- yaaN
- Gene Name
- caiB
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0020551|L-carnitine CoA-transferase MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQ LSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVI AHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAA LAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYK CADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWL ATHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKF KNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
- Number of residues
- 405
- Molecular Weight
- 45126.41
- Theoretical pI
- 4.89
- GO Classification
- Functionscarnitine dehydratase activity / CoA-transferase activityProcessescarnitine catabolic processComponentscytoplasm
- General Function
- Coa-transferase activity
- Specific Function
- Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
- Pfam Domain Function
- CoA_transf_3 (PF02515)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020552|L-carnitine CoA-transferase (caiB) ATGGATCATCTACCCATGCCGAAATTCGGGCCGTTGGCCGGATTGCGCGTTGTCTTCTCC GGTATCGAAATCGCCGGACCGTTTGCCGGGCAAATGTTCGCAGAATGGGGCGCGGAAGTT ATCTGGATCGAGAACGTCGCCTGGGCCGACACCATTCGCGTTCAACCGAACTACCCGCAA CTCTCCCGCCGCAATTTGCACGCGCTGTCGTTAAATATTTTCAAAGATGAAGGCCGCGAA GCGTTTCTGAAATTAATGGAAACCACCGATATCTTCATCGAAGCCAGTAAAGGTCCGGCC TTTGCCCGTCGTGGCATTACCGATGAAGTACTGTGGCAGCACAACCCGAAACTGGTTATC GCTCACCTGTCCGGTTTTGGTCAGTACGGCACCGAGGAGTACACCAATCTTCCGGCCTAT AACACTATCGCCCAGGCCTTTAGTGGTTACCTGATTCAGAACGGTGATGTTGACCAGCCA ATGCCTGCCTTCCCGTATACCGCCGATTACTTTTCTGGCCTGACCGCCACCACGGCGGCG CTGGCAGCACTGCATAAAGTGCGTGAAACCGGTAAAGGCGAAAGTATCGACATCGCCATG TATGAAGTGATGCTGCGTATGGGCCAGTACTTCATGATGGATTACTTCAACGGCGGCGAA ATGTGCCCGCGCATGAGCAAAGGTAAAGATCCCTACTACGCCGGTTGCGGTCTGTATAAA TGTGCCGACGGCTACATCGTGATGGAACTGGTGGGCATTACCCAAATTGAAGAGTGCTTT AAAGATATTGGCCTCGCACATCTGCTTGGCACGCCAGAAATCCCGGAAGGCACTCAGCTT ATCCACCGTATCGAATGCCCTTACGGCCCACTGGTTGAAGAGAAACTCGATGCCTGGCTG GCGACACATACCATCGCGGAAGTAAAAGAACGCTTTGCTGAACTGAATATCGCCTGCGCC AAAGTGCTGACCGTACCGGAACTGGAAAGCAATCCACAGTATGTGGCTCGCGAATCAATC ACTCAGTGGCAAACGATGGATGGTCGCACCTGCAAAGGGCCGAACATCATGCCGAAATTC AAAAATAACCCCGGACAAATCTGGCGCGGAATGCCCTCACATGGCATGGACACGGCTGCC ATTTTGAAAAATATCGGCTACAGCGAAAACGACATTCAGGAGTTGGTCAGCAAAGGTCTG GCCAAAGTTGAGGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P31572 UniProtKB Entry Name CAIB_ECOLI GenBank Protein ID 495242 GenBank Gene ID X67748 - General References
- Eichler K, Schunck WH, Kleber HP, Mandrand-Berthelot MA: Cloning, nucleotide sequence, and expression of the Escherichia coli gene encoding carnitine dehydratase. J Bacteriol. 1994 May;176(10):2970-5. [Article]
- Eichler K, Bourgis F, Buchet A, Kleber HP, Mandrand-Berthelot MA: Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli. Mol Microbiol. 1994 Sep;13(5):775-86. [Article]
- Yura T, Mori H, Nagai H, Nagata T, Ishihama A, Fujita N, Isono K, Mizobuchi K, Nakata A: Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region. Nucleic Acids Res. 1992 Jul 11;20(13):3305-8. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Elssner T, Engemann C, Baumgart K, Kleber HP: Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli. Biochemistry. 2001 Sep 18;40(37):11140-8. [Article]
- Elssner T, Preusser A, Wagner U, Kleber HP: Metabolism of L(-)-carnitine by Enterobacteriaceae under aerobic conditions. FEMS Microbiol Lett. 1999 May 15;174(2):295-301. [Article]
- Stenmark P, Gurmu D, Nordlund P: Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism. Biochemistry. 2004 Nov 9;43(44):13996-4003. [Article]