Spermidine/spermine N(1)-acetyltransferase
Details
- Name
- Spermidine/spermine N(1)-acetyltransferase
- Synonyms
- Protease synthase and sporulation negative regulatory protein PAI 1
- SAT
- Spermidine N(1)-acetyltransferase
- SSAT
- Gene Name
- paiA
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0011222|Spermidine/spermine N(1)-acetyltransferase MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESAFNTEQLEKELSNMSSQ FFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSFQKHGLGKHLLNKAIEIAL ERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDEEQTDLIMAKTLI
- Number of residues
- 172
- Molecular Weight
- 20014.605
- Theoretical pI
- 4.95
- GO Classification
- Functionsdiamine N-acetyltransferase activityProcessesnegative regulation of sporulation / sporulation resulting in formation of a cellular spore
- General Function
- Diamine n-acetyltransferase activity
- Specific Function
- Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1-acetyltransferase activity toward polyamine substrates including spermidine, spermine, aminopropylcadaverine, norspermidine, homospermidine, N(8)-acetylspermidine, diaminopropane and agmatine.
- Pfam Domain Function
- Acetyltransf_1 (PF00583)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011223|Spermidine/spermine N(1)-acetyltransferase (paiA) ATGAGTGTAAAAATGAAAAAATGCAGCCGGGAAGATTTACAAACACTTCAACAATTGAGT ATTGAAACATTCAATGACACTTTTAAAGAACAGAACTCACCTGAAAATATGAAAGCCTAT TTAGAAAGCGCATTTAACACTGAGCAGCTGGAAAAAGAGTTATCTAATATGTCTTCGCAA TTCTTTTTTATTTACTTTGATCATGAAATCGCTGGATATGTAAAGGTCAATATCGATGAT GCTCAGTCTGAAGAAATGGGTGCTGAATCACTTGAAATCGAGAGAATTTATATAAAGAAC AGCTTTCAAAAACATGGGCTTGGCAAACATCTGCTGAATAAAGCGATAGAAATTGCGCTG GAACGTAATAAAAAGAACATTTGGCTAGGTGTGTGGGAAAAAAATGAAAATGCCATTGCC TTTTATAAGAAAATGGGGTTTGTTCAGACCGGCGCCCACTCATTTTATATGGGTGATGAA GAACAAACGGATTTAATCATGGCTAAAACACTCATATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P21340 UniProtKB Entry Name PAIA_BACSU GenBank Protein ID 143284 GenBank Gene ID M36471 - General References
- Honjo M, Nakayama A, Fukazawa K, Kawamura K, Ando K, Hori M, Furutani Y: A novel Bacillus subtilis gene involved in negative control of sporulation and degradative-enzyme production. J Bacteriol. 1990 Apr;172(4):1783-90. [Article]
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- Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L: Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. J Biol Chem. 2005 Dec 2;280(48):40328-36. Epub 2005 Oct 6. [Article]