V-type proton ATPase subunit B, brain isoform
Details
- Name
- V-type proton ATPase subunit B, brain isoform
- Synonyms
- ATP6B2
- Endomembrane proton pump 58 kDa subunit
- HO57
- V-ATPase subunit B 2
- Vacuolar proton pump subunit B 2
- VPP3
- Gene Name
- ATP6V1B2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017231|V-type proton ATPase subunit B, brain isoform MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVIL DHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILR TPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGM NSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMET ARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDM SSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDD ITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSN QLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIG WQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
- Number of residues
- 511
- Molecular Weight
- 56500.21
- Theoretical pI
- 5.55
- GO Classification
- FunctionsATP binding / hydrogen ion transmembrane transporter activity / proton-transporting ATPase activity, rotational mechanismProcessesATP hydrolysis coupled proton transport / ATP metabolic process / cellular iron ion homeostasis / insulin receptor signaling pathway / ion transmembrane transport / phagosome maturation / proton transport / transferrin transport / transmembrane transportComponentscytosol / endomembrane system / extracellular exosome / integral component of membrane / intracellular membrane-bounded organelle / lysosomal membrane / melanosome / microvillus / myelin sheath / plasma membrane / proton-transporting V-type ATPase, V1 domain / ruffle
- General Function
- Proton-transporting atpase activity, rotational mechanism
- Specific Function
- Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Endomembrane system
- Gene sequence
>lcl|BSEQ0017232|V-type proton ATPase subunit B, brain isoform (ATP6V1B2) ATGGCGCTGCGGGCGATGCGGGGGATTGTCAACGGGGCCGCACCCGAGCTACCCGTGCCC ACCGGTGGGCCGGCGGTGGGAGCTCGGGAGCAGGCGCTGGCAGTCAGTCGGAACTACCTC TCCCAGCCTCGCCTCACATACAAGACAGTATCTGGAGTCAATGGTCCACTAGTGATCTTA GATCATGTTAAGTTTCCCAGGTATGCTGAAATTGTCCATTTGACCTTACCGGATGGCACA AAGAGAAGTGGGCAAGTTCTGGAAGTTAGTGGTTCCAAGGCAGTAGTTCAGGTATTTGAA GGGACTTCAGGTATAGATGCTAAGAAAACGTCCTGTGAGTTTACTGGGGATATTCTCCGA ACACCGGTGTCTGAGGATATGCTTGGTCGGGTATTCAATGGATCGGGAAAACCCATTGAC AGAGGTCCTGTTGTACTGGCCGAAGACTTCCTTGATATCATGGGTCAGCCAATCAACCCT CAATGTCGAATCTACCCAGAGGAAATGATTCAGACTGGCATTTCGGCCATCGATGGGATG AACAGTATTGCTAGGGGGCAGAAAATTCCTATCTTCTCTGCTGCTGGGCTACCACACAAT GAGATTGCAGCTCAGATCTGTCGCCAGGCTGGTTTGGTAAAGAAATCCAAAGATGTAGTA GACTACAGTGAGGAAAATTTTGCAATTGTATTTGCTGCTATGGGTGTAAACATGGAAACT GCCCGGTTCTTCAAATCTGACTTTGAAGAAAATGGCTCAATGGACAATGTCTGCCTCTTT TTGAACTTGGCTAATGACCCAACCATTGAGCGAATTATCACTCCTCGCCTGGCTCTAACC ACAGCTGAATTTCTGGCGTACCAATGTGAGAAACATGTATTGGTTATTCTAACAGACATG AGTTCTTATGCTGAAGCACTTCGAGAGGTTTCAGCAGCCAGGGAAGAGGTACCTGGTCGA CGAGGTTTTCCAGGTTACATGTATACAGATTTAGCCACGATATATGAACGCGCTGGGCGA GTGGAAGGGAGAAACGGCTCGATTACTCAAATCCCTATTCTAACCATGCCTAATGATGAT ATCACTCACCCCATCCCAGACTTGACTGGCTACATTACAGAGGGGCAGATCTATGTGGAC AGACAGCTGCACAACAGACAGATTTATCCACCTATCAATGTGCTGCCCTCACTATCACGG TTAATGAAGTCTGCTATTGGAGAAGGGATGACCAGGAAGGATCATGCCGATGTATCTAAC CAGCTATATGCGTGCTATGCTATTGGAAAGGATGTGCAAGCCATGAAAGCTGTCGTTGGA GAAGAAGCCCTTACCTCAGATGATCTTCTCTACTTGGAATTTCTGCAGAAGTTTGAGAGG AACTTCATTGCTCAGGGTCCTTACGAAAATCGCACTGTCTTTGAGACTTTGGACATTGGC TGGCAGCTACTCCGAATCTTCCCCAAAGAAATGCTGAAGAGAATCCCTCAGAGCACCCTC AGCGAATTTTACCCTCGAGACTCTGCAAAGCATTAG
- Chromosome Location
- 8
- Locus
- 8p22-p21
- External Identifiers
Resource Link UniProtKB ID P21281 UniProtKB Entry Name VATB2_HUMAN GenBank Protein ID 179563 GenBank Gene ID M60346 HGNC ID HGNC:854 - General References
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- van Hille B, Richener H, Schmid P, Puettner I, Green JR, Bilbe G: Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms. Biochem J. 1994 Oct 1;303 ( Pt 1):191-8. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB07347 4-(2-Aminoethyl)Benzenesulfonyl Fluoride experimental unknown Details DB05260 Gallium nitrate approved, investigational unknown inhibitor Details DB01133 Tiludronic acid approved, investigational, vet_approved unknown inhibitor Details