Glucose-6-phosphate 1-dehydrogenase
Details
- Name
- Glucose-6-phosphate 1-dehydrogenase
- Synonyms
- 1.1.1.49
- G6PD
- Gene Name
- zwf
- Organism
- Leuconostoc mesenteroides
- Amino acid sequence
>lcl|BSEQ0022275|Glucose-6-phosphate 1-dehydrogenase MVSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALNDDEFKQLVR DSIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIEEAADKFDIDGNRIFYMSVA PRFFGTIAKYLKSEGLLADTGYNRLMIEKPFGTSYDTAAELQNDLENAFDDNQLFRIDHY LGKEMVQNIAALRFGNPIFDAAWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQN HTMQIVGWLAMEKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKP YLEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIVFKAGTFNFG SEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLGWTVSDEDKKNTPEPYERMI HDTMNGDGSNFADWNGVSIAWKFVDAISAVYTADKAPLETYKSGSMGPEASDKLLAANGD AWVFKG
- Number of residues
- 486
- Molecular Weight
- 54440.585
- Theoretical pI
- 4.57
- GO Classification
- Functionsglucose-6-phosphate dehydrogenase activity / NADP bindingProcessesglucose metabolic process / pentose-phosphate shunt
- General Function
- Nadp binding
- Specific Function
- Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Can utilize either NADP(+) or NAD(+).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002855|1461 bp ATGGTTTCAGAAATCAAGACGTTAGTAACTTTCTTTGGTGGCACTGGTGACTTGGCCAAG CGTAAGCTTTACCCATCAGTTTTCAATCTTTATAAAAAAGGCTACTTGCAAAAGCATTTT GCCATTGTTGGAACGGCCCGTCAAGCCCTCAATGATGACGAATTCAAACAATTGGTTCGT GATTCAATTAAAGATTTCACTGACGATCAAGCACAAGCTGAGGCGTTCATCGAACATTTC TCATACCGTGCACACGACGTAACAGATGCTGCTTCATACGCTGTTTTAAAAGAGGCGATT GAAGAAGCTGCCGACAAATTTGATATCGATGGCAACCGCATTTTCTATATGTCAGTTGCG CCACGTTTCTTTGGTACAATTGCCAAATATCTTAAGTCAGAAGGCCTACTAGCTGACACT GGTTACAACCGTTTGATGATTGAAAAGCCTTTCGGTACATCATATGACACAGCTGCCGAA CTCCAAAATGACTTGGAAAACGCATTTGATGATAACCAACTATTCCGTATTGACCACTAC CTTGGTAAGGAAATGGTTCAAAACATTGCTGCCCTTCGCTTTGGTAACCCAATTTTCGAT GCTGCTTGGAACAAGGATTACATCAAGAACGTTCAAGTAACATTGTCAGAAGTCTTGGGT GTCGAAGAACGTGCCGGCTACTATGACACAGCCGGTGCATTGCTTGACATGATTCAAAAC CACACCATGCAAATTGTTGGTTGGTTAGCCATGGAAAAACCAGAATCATTCACTGACAAA GACATTCGTGCCGCTAAAAACGCAGCCTTTAATGCTTTGAAGATCTATGATGAAGCAGAA GTTAACAAATACTTTGTTCGTGCACAATATGGTGCCGGTGATTCAGCTGACTTCAAGCCA TACCTTGAAGAATTAGACGTACCTGCTGATTCTAAAAACAATACCTTCATCGCCGGCGAA TTGCAATTTGATTTGCCACGTTGGGAGGGTGTCCCATTCTATGTCCGTTCAGGTAAGCGC TTAGCTGCTAAACAGACACGGGTTGATATCGTCTTTAAGGCTGGCACGTTTAACTTTGGT TCAGAACAAGAAGCACAAGAAGCTGTCTTGTCAATTATCATTGATCCAAAGGGTGCTATC GAATTGAAGTTGAACGCCAAGTCAGTTGAAGATGCTTTCAACACACGTACAATTGACTTA GGTTGGACTGTATCTGACGAAGATAAGAAGAACACGCCAGAACCATACGAACGTATGATT CACGACACTATGAATGGTGATGGCTCTAACTTCGCTGACTGGAATGGCGTTTCAATCGCT TGGAAGTTCGTTGATGCTATTTCAGCCGTTTATACCGCAGATAAAGCACCACTTGAAACT TACAAGTCGGGCTCAATGGGTCCTGAAGCATCCGATAAATTATTGGCTGCCAATGGTGAT GCTTGGGTGTTTAAAGGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P11411 UniProtKB Entry Name G6PD_LEUME GenBank Protein ID 149631 GenBank Gene ID M64446 - General References
- Lee WT, Flynn TG, Lyons C, Levy HR: Cloning of the gene and amino acid sequence for glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. J Biol Chem. 1991 Jul 15;266(20):13028-34. [Article]
- Bhadbhade MM, Adams MJ, Flynn TG, Levy HR: Sequence identity between a lysine-containing peptide from Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase and an active site peptide from human erythrocyte glucose-6-phosphate dehydrogenase. FEBS Lett. 1987 Jan 26;211(2):243-6. [Article]
- Olive C, Geroch ME, Levy HR: Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies. J Biol Chem. 1971 Apr 10;246(7):2047-57. [Article]
- Lee WT, Levy HR: Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction. Protein Sci. 1992 Mar;1(3):329-34. [Article]
- Vought V, Ciccone T, Davino MH, Fairbairn L, Lin Y, Cosgrove MS, Adams MJ, Levy HR: Delineation of the roles of amino acids involved in the catalytic functions of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase. Biochemistry. 2000 Dec 12;39(49):15012-21. [Article]
- Rowland P, Basak AK, Gover S, Levy HR, Adams MJ: The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution. Structure. 1994 Nov 15;2(11):1073-87. [Article]
- Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR: On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase. Biochemistry. 1998 Mar 3;37(9):2759-67. [Article]
- Cosgrove MS, Gover S, Naylor CE, Vandeputte-Rutten L, Adams MJ, Levy HR: An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme. Biochemistry. 2000 Dec 12;39(49):15002-11. [Article]
- Naylor CE, Gover S, Basak AK, Cosgrove MS, Levy HR, Adams MJ: NADP+ and NAD+ binding to the dual coenzyme specific enzyme Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: different interdomain hinge angles are seen in different binary and ternary complexes. Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):635-48. Epub 2001 Apr 24. [Article]