Inosine-5'-monophosphate dehydrogenase
Details
- Name
- Inosine-5'-monophosphate dehydrogenase
- Synonyms
- 1.1.1.205
- IMP dehydrogenase
- impD
- Gene Name
- guaB
- Organism
- Streptococcus pyogenes
- Amino acid sequence
>lcl|BSEQ0016659|Inosine-5'-monophosphate dehydrogenase MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSK MAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRY RISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERIL HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG NAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP EGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHD VQITNEAPNYSVH
- Number of residues
- 493
- Molecular Weight
- 52806.77
- Theoretical pI
- 5.88
- GO Classification
- FunctionsIMP dehydrogenase activity / metal ion bindingProcessesGMP biosynthetic process
- General Function
- Metal ion binding
- Specific Function
- Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0004042|1482 bp ATGTCAAATTGGGACACTAAATTTTTAAAAAAAGGCTACACTTTTGACGATGTCTTGCTT ATTCCGGCAGAGAGTCATGTTCTTCCAAATGAAGTTGATTTAAAGACAAAACTCGCAGAC AATTTGACATTAAATATTCCTATTATTACAGCAGCTATGGATACGGTTACTGGTAGTAAA ATGGCTATTGCAATTGCGCGTGCGGGTGGTTTAGGTGTTATTCATAAAAACATGTCTATT ACTGAGCAAGCAGAAGAAGTTCGCAAGGTAAAACGTTCTGAAAATGGTGTCATCATTGAT CCATTCTTCTTAACACCTGAACACAAGGTTTCAGAAGCTGAAGAATTAATGCAGCGCTAC CGTATCAGTGGTGTGCCAATTGTTGAAACTTTAGCAAACCGTAAGTTGGTCGGTATCATT ACTAATCGTGATATGCGTTTTATTTCTGATTACAATGCACCAATCTCTGAACATATGACT AGTGAGCACCTCGTTACGGCTGCTGTTGGTACAGATCTTGAAACTGCAGAACGTATTCTT CATGAACACCGTATTGAAAAACTTCCTTTGGTTGATAATAGCGGTCGTCTATCTGGTTTA ATCACTATCAAAGATATTGAAAAAGTAATCGAATTCCCACATGCTGCTAAAGATGAATTT GGTCGTCTTCTGGTCGCTGCTGCGGTAGGTGTTACCTCAGATACTTTTGAGCGTGCCGAG GCCTTGTTTGAAGCTGGTGCAGATGCGATTGTTATTGACACAGCTCATGGTCATTCGGCT GGTGTTCTTCGTAAAATTGCTGAGATTCGTGCTCATTTCCCAAATCGTACTTTGATTGCT GGAAATATTGCCACTGCTGAAGGTGCGCGTGCTCTTTATGATGCAGGTGTTGATGTTGTT AAAGTGGGTATTGGTCCCGGATCTATCTGTACCACTCGTGTGGTTGCAGGTGTCGGTGTT CCTCAAGTGACTGCTATTTACGATGCTGCTGCTGTTGCTCGTGAATATGGCAAAACGATT ATTGCTGATGGTGGTATCAAGTATTCTGGCGATATTGTTAAGGCTCTTGCAGCCGGTGGT AATGCTGTTATGCTTGGATCAATGTTTGCAGGTACTGATGAAGCTCCAGGTGAAACTGAA ATCTACCAAGGCCGTAAGTTCAAAACTTATCGTGGAATGGGTTCCATTGCAGCTATGAAG AAAGGATCAAGCGATCGTTACTTCCAAGGTTCCGTCAATGAAGCTAATAAACTAGTTCCA GAAGGTATTGAAGGCCGTGTTGCTTATAAAGGAGCTGCTTCAGATATTGTCTTCCAAATG TTAGGTGGTATCCGCTCAGGTATGGGCTATGTTGGCGCAGGTGACATTCAAGAATTACAT GAAAATGCTCAATTTGTTGAAATGTCAGGTGCAGGCTTGATTGAAAGTCATCCACATGAT GTTCAAATCACAAATGAAGCACCAAACTATTCTGTGCACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0C0H6 UniProtKB Entry Name IMDH_STRPY GenBank Protein ID 924848 GenBank Gene ID U26056 - General References
- Ashbaugh CD, Wessels MR: Cloning, sequence analysis and expression of the group A streptococcal guaB gene encoding inosine monophosphate dehydrogenase. Gene. 1995 Nov 7;165(1):57-60. [Article]
- Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR: Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. Biochemistry. 1999 Apr 13;38(15):4691-700. [Article]