Pro-cathepsin H
Details
- Name
- Pro-cathepsin H
- Synonyms
- CPSB
- Gene Name
- CTSH
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012762|Pro-cathepsin H MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
- Number of residues
- 335
- Molecular Weight
- 37393.43
- Theoretical pI
- 8.19
- GO Classification
- Functionsaminopeptidase activity / cysteine-type endopeptidase activator activity involved in apoptotic process / cysteine-type endopeptidase activity / cysteine-type peptidase activity / endopeptidase activity / HLA-A specific activating MHC class I receptor activity / peptidase activity / serine-type endopeptidase activity / thyroid hormone bindingProcessesactivation of cysteine-type endopeptidase activity involved in apoptotic process / adaptive immune response / antigen processing and presentation / bradykinin catabolic process / cellular protein metabolic process / cellular response to thyroid hormone stimulus / dichotomous subdivision of terminal units involved in lung branching / ERK1 and ERK2 cascade / immune response-regulating signaling pathway / membrane protein proteolysis / metanephros development / negative regulation of apoptotic process / neuropeptide catabolic process / positive regulation of angiogenesis / positive regulation of apoptotic signaling pathway / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of epithelial cell migration / positive regulation of gene expression / positive regulation of peptidase activity / protein destabilization / proteolysis / proteolysis involved in cellular protein catabolic process / response to retinoic acid / surfactant homeostasis / T cell mediated cytotoxicity / zymogen activationComponentsalveolar lamellar body / cytosol / extracellular exosome / extracellular space / lysosome / multivesicular body lumen
- General Function
- Thyroid hormone binding
- Specific Function
- Important for the overall degradation of proteins in lysosomes.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Lysosome
- Gene sequence
>lcl|BSEQ0012763|Pro-cathepsin H (CTSH) ATGTGGGCCACGCTGCCGCTGCTCTGCGCCGGGGCCTGGCTCCTGGGAGTCCCCGTCTGC GGTGCCGCCGAACTGTGCGTGAACTCCTTAGAGAAGTTTCACTTCAAGTCATGGATGTCT AAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTGCAGACGTTTGCCAGC AACTGGAGGAAGATAAACGCCCACAACAATGGGAACCACACATTTAAAATGGCACTGAAC CAATTTTCAGACATGAGCTTTGCTGAAATAAAACACAAGTATCTCTGGTCAGAGCCTCAG AATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCCTACCCACCTTCCGTG GACTGGCGGAAAAAAGGAAATTTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGT TGCTGGACTTTCTCCACCACTGGGGCCCTGGAGTCTGCGATCGCCATCGCAACCGGAAAG ATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGACTTCAATAATCACGGC TGCCAAGGGGGTCTCCCCAGCCAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATG GGTGAAGACACCTACCCCTACCAGGGCAAGGATGGTTATTGCAAGTTCCAACCTGGAAAG GCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGACGAGGAAGCGATGGTG GAGGCTGTGGCCCTCTACAACCCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATG ATGTATAGAACGGGCATCTACTCCAGTACTTCCTGCCATAAAACTCCAGATAAAGTAAAC CATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCTTACTGGATCGTGAAA AACTCTTGGGGTCCCCAGTGGGGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAAC ATGTGTGGCCTGGCTGCCTGCGCCTCCTACCCCATCCCTCTGGTGTGA
- Chromosome Location
- 15
- Locus
- 15q24-q25
- External Identifiers
Resource Link UniProtKB ID P09668 UniProtKB Entry Name CATH_HUMAN GenBank Protein ID 29708 GenBank Gene ID X07549 HGNC ID HGNC:2535 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03120 p-Toluenesulfonic acid experimental unknown Details DB02140 N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide experimental unknown Details DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane experimental unknown Details DB08526 CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE experimental unknown Details