Aklanonic acid methyl ester cyclase AcmA
Details
- Name
- Aklanonic acid methyl ester cyclase AcmA
- Synonyms
- 5.5.1.23
- AAME cyclase
- aknH
- Methyl aklanonate cyclase
- Gene Name
- acma
- Organism
- Streptomyces galilaeus
- Amino acid sequence
>lcl|BSEQ0022075|Aklanonic acid methyl ester cyclase AcmA MSEQIAAVRRMVEAYNTGKTDDVADYIHPEYMNPGTLEFTSLRGPELFAINVAWVKKTFS EEARLEEVGIEERADWVRARLVLYGRHVGEMVGMAPTGRLFSGEQIHLLHFVDGKIHHHR DWPDYQGTYRQLGEPWPETEHRRP
- Number of residues
- 144
- Molecular Weight
- 16730.765
- Theoretical pI
- 6.08
- GO Classification
- Functionsintramolecular lyase activityProcessesantibiotic biosynthetic process / daunorubicin biosynthetic process / doxorubicin metabolic process
- General Function
- Not Available
- Specific Function
- Not Available
- Pfam Domain Function
- SnoaL (PF07366)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006516|435 bp GTGAGTGAGCAGATAGCGGCCGTTCGGCGCATGGTCGAGGCGTACAACACCGGAAAAACG GATGATGTGGCCGACTACATCCATCCGGAATACATGAATCCGGGAACCCTGGAATTCACC TCGCTGCGTGGCCCGGAACTCTTCGCGATCAATGTCGCGTGGGTCAAGAAGACGTTCTCC GAGGAGGCGCGGCTGGAAGAGGTCGGCATCGAGGAGCGGGCCGACTGGGTGCGCGCCCGG CTGGTGCTCTACGGCCGGCACGTCGGTGAGATGGTCGGCATGGCGCCGACCGGACGGCTG TTCTCCGGCGAGCAGATCCATCTCCTGCACTTCGTCGACGGGAAGATCCACCACCACCGC GACTGGCCCGACTACCAGGGCACCTACCGCCAGCTCGGCGAGCCGTGGCCGGAGACCGAG CACCGCCGTCCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O52646 UniProtKB Entry Name DNRD_STRGJ GenBank Gene ID AF043550 - General References
- Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P: Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp. Microbiology. 2000 Jan;146 ( Pt 1):155-63. [Article]
- Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P: Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster. Gene. 2002 Jun 26;293(1-2):115-22. [Article]
- Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y: Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22. [Article]
- Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G: Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol. 2006 Mar 17;357(1):210-20. Epub 2006 Jan 6. [Article]