Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Details
- Name
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Synonyms
- 2.7.1.154
- C2-PI3K
- Phosphoinositide 3-kinase-C2-beta
- PI3K-C2-beta
- Gene Name
- PIK3C2B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051906|Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK TGWFALGSRSHGTL
- Number of residues
- 1634
- Molecular Weight
- 184766.065
- Theoretical pI
- Not Available
- GO Classification
- Functions1-phosphatidylinositol-3-kinase activity / 1-phosphatidylinositol-4-phosphate 3-kinase activity / ATP binding / lipid kinase activity / phosphatidylinositol bindingProcessesautophagosome organization / cell migration / cellular response to starvation / phosphatidylinositol 3-kinase signaling / phosphatidylinositol biosynthetic process / protein kinase B signalingComponentscytoplasm / cytosol / endocytic vesicle / endoplasmic reticulum / nucleoplasm / phosphatidylinositol 3-kinase complex / plasma membrane
- General Function
- Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
- Specific Function
- 1-phosphatidylinositol-3-kinase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Microsome
- Gene sequence
>lcl|BSEQ0051907|Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) ATGTCTTCGACTCAGGGCAATGGGGAACACTGGAAGTCCCTGGAGTCAGTGGGCATCAGC CGCAAAGAGCTAGCGATGGCCGAAGCCCTGCAGATGGAGTATGATGCCCTGTCCCGGCTC CGGCATGACAAGGAGGAGAACAGAGCCAAGCAGAACGCAGACCCCTCTCTCATCAGCTGG GATGAGCCTGGGGTAGACTTTTACAGCAAGCCAGCAGGAAGGCGGACCGACCTCAAGCTG TTACGCGGTCTCTCTGGCTCTGATCCTACCCTTAACTACAACTCACTCTCCCCACAGGAA GGGCCGCCCAACCACTCTACCTCCCAAGGGCCACAGCCTGGCTCAGATCCCTGGCCCAAA GGCTCCCTGTCTGGAGACTATCTCTACATTTTTGATGGTTCAGATGGGGGAGTCTCTTCG TCCCCAGGACCAGGGGACATAGAGGGCTCTTGCAAGAAACTATCCCCACCTCCTCTGCCT CCCCGAGCTTCTATCTGGGATACCCCTCCCCTGCCTCCCAGAAAGGGGTCCCCCTCATCC TCCAAGATCTCCCAGCCCAGTGACATCAACACTTTCTCTTTGGTCGAACAATTGCCGGGC AAACTGCTAGAGCATCGGATCCTAGAAGAGGAAGAGGTGCTGGGAGGTGGGGGTCAGGGG CGCCTACTGGGGTCTGTGGACTATGATGGTATCAATGATGCAATTACTAGGCTCAACTTG AAATCGACCTATGATGCGGAGATGTTGCGGGATGCCACCAGGGGCTGGAAGGAGGGCCGA GGGCCGCTGGACTTCAGCAAAGACACCTCTGGAAAACCCGTGGCCAGGAGCAAGACTATG CCCCCTCAGGTGCCCCCCCGCACCTATGCCTCCCGCTATGGCAACCGAAAGAATGCGACG CCTGGCAAGAACCGCCGGATTTCTGCAGCCCCGGTGGGCTCCCGGCCCCACACTGTTGCC AATGGCCATGAGTTGTTTGAGGTCTCAGAAGAGAGAGATGAGGAGGTTGCTGCATTTTGC CACATGCTGGATATCCTTCGATCTGGCTCTGACATCCAAGACTACTTCCTCACTGGCTAT GTCTGGAGTGCTGTCACCCCTAGCCCAGAGCACCTCGGGGATGAGGTCAACCTGAAGGTG ACTGTGTTGTGTGACAGGCTTCAAGAGGCACTCACTTTCACCTGCAACTGTTCCTCCACT GTAGACTTGCTTATCTACCAGACCCTGTGCTACACCCATGATGACCTGAGGAATGTGGAC GTGGGTGACTTTGTGCTAAAGCCCTGCGGGCTGGAGGAGTTCCTGCAGAACAAGCATGCC TTGGGCAGTCATGAGTACATCCAATACTGCCGCAAGTTTGACATTGACATTCGGCTACAG CTGATGGAGCAGAAGGTTGTGCGCAGTGACCTGGCCCGGACGGTGAATGATGACCAGAGC CCCTCCACCTTGAACTACCTCGTCCATCTCCAAGAGAGGCCTGTCAAGCAGACCATCAGC AGGCAGGCCCTGAGTCTTCTGTTCGACACTTACCACAATGAGGTGGATGCCTTCCTGCTG GCTGATGGAGACTTCCCACTGAAGGCTGACAGGGTGGTCCAGTCCGTCAAGGCCATCTGC AACGCCCTGGCCGCCGTGGAAACCCCTGAGATCACCAGTGCTCTCAACCAGCTGCCCCCC TGCCCCTCCCGCATGCAGCCTAAAATTCAGAAGGATCCCAGTGTCTTGGCTGTGAGGGAA AACCGAGAGAAGGTCGTGGAAGCCCTGACCGCTGCCATCTTGGACCTGGTGGAGCTGTAC TGCAACACATTCAACGCAGACTTCCAGACGGCAGTGCCCGGGAGCCGCAAGCATGACCTG GTCCAGGAGGCCTGCCATTTCGCCAGGTCCCTGGCCTTCACTGTCTATGCCACCCACCGC ATCCCCATCATCTGGGCTACCAGCTATGAAGATTTCTACCTCTCCTGCTCCCTCAGCCAT GGCGGCAAGGAGCTGTGCAGCCCCCTGCAGACCCGAAGAGCTCACTTCTCCAAGTACCTC TTCCACCTCATCGTCTGGGACCAGCAGATCTGCTTCCCAGTGCAGGTGAACCGGCTGCCT CGGGAGACACTGCTGTGTGCCACTCTCTATGCTCTGCCCATCCCCCCACCGGGGAGCTCC TCAGAGGCCAATAAGCAGCGGCGGGTGCCTGAAGCCCTGGGCTGGGTCACTACCCCACTC TTCAACTTCAGGCAGGTCCTGACCTGTGGCCGGAAGCTTCTGGGTTTGTGGCCAGCAACA CAGGAAAATCCCAGCGCCCGTTGGAGTGCACCTAATTTCCACCAGCCAGACAGTGTCATC CTGCAGATTGACTTCCCCACCTCGGCCTTTGACATCAAGTTCACCAGCCCCCCTGGAGAC AAGTTCAGCCCCCGCTATGAGTTTGGCAGCCTCCGGGAAGAAGACCAGCGCAAGCTTAAA GACATCATGCAGAAAGAGTCCTTGTACTGGCTCACTGATGCTGACAAGAAGCGCCTGTGG GAGAAGCGATATTACTGCCACTCGGAGGTGAGCTCGCTCCCCCTGGTGCTCGCCAGCGCC CCCAGCTGGGAGTGGGCTTGCCTGCCTGACATCTATGTTCTCCTGAAGCAGTGGACCCAC ATGAACCACCAGGATGCCCTGGGGCTCCTGCATGCCACCTTCCCGGACCAGGAGGTGCGT CGTATGGCTGTGCAGTGGATTGGCTCACTCTCAGATGCTGAGCTGCTAGACTACCTGCCC CAGCTGGTACAGGCCCTGAAGTATGAATGCTACCTGGACAGCCCGTTGGTGCGCTTCCTC CTGAAACGAGCTGTGTCTGACTTGAGAGTGACTCACTACTTCTTCTGGTTACTGAAGGAC GGCCTCAAGGACTCTCAGTTCAGCATCCGCTACCAGTATCTGCTGGCAGCCTTACTGTGC TGCTGTGGCAAGGGGCTGAGAGAAGAGTTTAACCGCCAGTGCTGGCTTGTCAATGCCCTG GCCAAACTGGCCCAGCAGGTCCGGGAGGCAGCCCCATCTGCAAGGCAGGGAATCCTCCGC ACGGGCCTGGAGGAGGTGAAGCAGTTCTTTGCCCTCAATGGCTCGTGCCGCTTGCCACTC AGCCCCAGTCTGCTGGTTAAGGGAATTGTGCCCAGGGACTGTTCCTACTTCAACTCCAAT GCTGTCCCCCTCAAACTCTCCTTCCAAAATGTGGATCCCCTGGGTGAGAACATCCGTGTC ATCTTCAAGTGTGGGGACGACCTTCGCCAGGACATGCTAACGCTGCAGATGATTCGCATC ATGAGCAAGATCTGGGTCCAGGAGGGGCTGGACATGCGCATGGTCATCTTCCGCTGCTTC TCCACCGGCCGGGGCAGAGGGATGGTGGAGATGATCCCTAATGCTGAGACCCTGCGTAAG ATCCAGGTGGAGCATGGGGTGACCGGCTCGTTCAAGGACCGGCCCCTGGCAGACTGGCTG CAGAAACACAACCCTGGGGAGGACGAGTATGAGAAGGCTGTGGAGAACTTTATCTACTCC TGCGCTGGCTGCTGCGTGGCCACGTACGTCTTGGGCATCTGTGACCGACATAATGACAAC ATCATGCTGAAGACCACTGGTCACATGTTCCACATTGATTTTGGCCGCTTCCTGGGCCAT GCCCAGATGTTTGGCAACATCAAGCGGGACCGTGCCCCCTTTGTCTTCACCTCGGACATG GCGTATGTCATCAACGGGGGTGACAAGCCTTCCAGCCGCTTCCATGATTTTGTTGACCTT TGCTGCCAAGCCTACAACCTCATTCGCAAGCACACCCACCTCTTCCTCAACCTTCTGGGC CTGATGTTGTCCTGTGGGATCCCTGAACTCTCAGACCTGGAGGACCTCAAGTATGTGTAC GATGCCCTGAGGCCTCAGGATACAGAGGCCAATGCCACTACCTACTTCACTAGGTTGATT GAGTCCAGCCTGGGCAGTGTAGCCACAAAGCTCAATTTTTTCATCCATAATCTGGCTCAG ATGAAGTTCACGGGCTCAGATGACCGGCTGACCCTCTCCTTTGCCTCCCGAACACACACT CTCAAGAGCTCTGGCCGAATCAGTGATGTTTTCCTCTGCCGCCATGAGAAGATCTTCCAC CCCAACAAAGGCTATATATATGTGGTAAAGGTGATGCGAGAGAACACTCACGAGGCCACC TACATCCAGCGGACCTTTGAGGAGTTCCAGGAATTACACAATAAGTTGCGGCTGCTCTTC CCTTCTTCCCACTTGCCCAGCTTCCCTAGTCGCTTCGTGATCGGCCGCTCCCGGGGAGAG GCGGTGGCCGAGCGGCGGAGGGAGGAGCTAAACGGTTACATCTGGCACTTGATCCACGCA CCCCCTGAGGTGGCCGAGTGTGATTTGGTGTACACCTTCTTCCACCCACTGCCCCGGGAT GAGAAGGCTATGGGCACCAGCCCAGCTCCTAAGTCCTCAGATGGCACATGGGCCCGGCCC GTCGGAAAGGTGGGAGGGGAGGTGAAGCTGTCCATCTCCTACAAAAACAATAAACTCTTC ATCATGGTGATGCATATTCGGGGCTTGCAACTGCTCCAGGATGGAAATGACCCTGACCCC TATGTGAAAATTTACCTCCTTCCTGACCCTCAGAAAACCACTAAGAGGAAAACCAAAGTG GCCCGGAAAACCTGCAATCCTACCTACAATGAGATGTTGGTATATGATGGGATCCCCAAG GGTGACCTGCAGCAGCGGGAGCTCCAGCTGAGCGTGCTGAGTGAGCAGGGATTCTGGGAG AACGTCCTCCTCGGTGAGGTGAACATCCGCCTGCGAGAGCTGGACCTGGCTCAGGAGAAG ACCGGCTGGTTCGCCCTGGGATCTCGAAGTCATGGCACCTTGTGA
- Chromosome Location
- 1
- Locus
- 1q32.1
- External Identifiers
Resource Link UniProtKB ID O00750 UniProtKB Entry Name P3C2B_HUMAN HGNC ID HGNC:8972 - General References
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