Aficamten
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Aficamten
- DrugBank Accession Number
- DB18490
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 337.383
Monoisotopic: 337.153874872 - Chemical Formula
- C18H19N5O2
- Synonyms
- 1h-pyrazole-4-carboxamide, n-((1r)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-
- N-((1r)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)- 1-methyl-1h-pyrazole-4-carboxamide
- External IDs
- CK-3773274
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- B1I77MH6K1
- CAS number
- 2364554-48-1
- InChI Key
- IOVAZWDIRCRMTM-OAHLLOKOSA-N
- InChI
- InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1
- IUPAC Name
- N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-pyrazole-4-carboxamide
- SMILES
- CCC1=NC(=NO1)C1=CC=C2[C@@H](CCC2=C1)NC(=O)C1=CN(C)N=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 114935503
- ChEMBL
- CHEMBL4847050
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Obstructive Hypertrophic Cardiomyopathy (oHCM) 1 3 Recruiting Treatment Obstructive Hypertrophic Cardiomyopathy 1 3 Recruiting Treatment Obstructive Hypertrophic Cardiomyopathy (oHCM) 1 3 Recruiting Treatment Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy 1 2 Completed Treatment Hypertrophic Cardiomyopathy (HCM) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.6 Chemaxon pKa (Strongest Acidic) 13.41 Chemaxon pKa (Strongest Basic) 1.24 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 85.84 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 116.22 m3·mol-1 Chemaxon Polarizability 37.14 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 27, 2023 19:28 / Updated at September 28, 2023 05:41