WP-1122
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- WP-1122
- DrugBank Accession Number
- DB17192
- Background
WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). It was granted FDA orphan designation for the treatment of glioblastoma multiforme.1
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 248.231
Monoisotopic: 248.089602855 - Chemical Formula
- C10H16O7
- Synonyms
- 3,6-di-O-acetyl-2-deoxy-D-glucopyranose
- an acetic acid diester of 2-deoxy-D-glucose
- External IDs
- WP 1122
- WP1122
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 54EAA28C5Y
- CAS number
- Not Available
- InChI Key
- BYPTXUKSDKAPKO-OPRDCNLKSA-N
- InChI
- InChI=1S/C10H16O7/c1-6(12)16-5-8(14)10(15)9(3-4-11)17-7(2)13/h4,8-10,14-15H,3,5H2,1-2H3/t8-,9-,10-/m1/s1
- IUPAC Name
- (3R,4R,5R)-6-(acetyloxy)-4,5-dihydroxy-1-oxohexan-3-yl acetate
- SMILES
- [H][C@@](O)(COC(C)=O)[C@@]([H])(O)[C@@]([H])(CC=O)OC(C)=O
References
- General References
- OncLive: FDA Grants Orphan Drug Designation to WP1122 for Glioblastoma Multiforme [Link]
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Treatment Coronavirus Disease 2019 (COVID‑19) / Healthy Volunteers (HV) 1 1, 2 Not Yet Recruiting Treatment Acute Respiratory Distress Syndrome Caused by COVID-19 / Coronavirus Disease 2019 (COVID‑19) / Mechanical Ventilation Complication 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 86.4 mg/mL ALOGPS logP -0.72 ALOGPS logP -2 Chemaxon logS -0.46 ALOGPS pKa (Strongest Acidic) 12.91 Chemaxon pKa (Strongest Basic) -3.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 110.13 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 54.31 m3·mol-1 Chemaxon Polarizability 23.35 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 24, 2022 21:15 / Updated at July 18, 2023 22:58