NAV

Human umbilical cord blood mononuclear cell-conditioned medium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Human umbilical cord blood mononuclear cell-conditioned medium
DrugBank Accession Number
DB15724
Background

Transplantation with human umbilical cord blood mononuclear cells (HUCBC) has demonstrated promising results in various disease states. While some of the positive results are credited to HUCBCs’ differentiation potential, the growth factors and cytokines these cells secrete are also implicated. When HUCBCs secrete growth factors and anti-inflammatory cytokines, they are thought to reduce inflammation and associated damage. Thus, the media in which they are cultured is believed to also have therapeutic potential.

After the human umbilical cord mononuclear cells are extracted from the umbilical cord, they are expanded and cultured in Dulbecco’s modified Eagle’s medium. Then, the medium is filtered and separated from the HUCBCs.

Type
Biotech
Groups
Investigational
Biologic Classification
Cell transplant therapies
Other cell transplant therapies
Synonyms
  • Umbilical Cord Blood Mononuclear Cells Conditioned Medium
External IDs
  • Human umbilical cord blood mononuclear cell-conditioned medium
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

Mononuclear umbilical cord cells have the ability to secrete cytokines, growth factors, interleukins,and chemokines. As many of these factors can have anti-inflammatory, angiogenic, and neuroprotective effects, it is thought that the conditioned media may exert some therapeutic potential related to these effects.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Jin H, Sanberg PR, Henning RJ: Human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein Akt. Cell Transplant. 2013;22(9):1637-50. doi: 10.3727/096368912X661427. Epub 2013 Jan 16. [Article]
  2. Neuhoff S, Moers J, Rieks M, Grunwald T, Jensen A, Dermietzel R, Meier C: Proliferation, differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro. Exp Hematol. 2007 Jul;35(7):1119-31. doi: 10.1016/j.exphem.2007.03.019. [Article]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at August 11, 2020 18:34 / Updated at August 13, 2020 07:02