Ampreloxetine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Ampreloxetine
- DrugBank Accession Number
- DB15348
- Background
Ampreloxetine is under investigation in clinical trial NCT03750552 (Clinical Effect of TD-9855 for Treating snOH in Subjects With Primary Autonomic Failure).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 321.343
Monoisotopic: 321.134048693 - Chemical Formula
- C18H18F3NO
- Synonyms
- Ampreloxetine
- External IDs
- TD-9855
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 19997EZ42I
- CAS number
- 1227056-84-9
- InChI Key
- TZIALEBTHQWNAO-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H18F3NO/c19-14-9-16(20)18(17(21)10-14)23-11-13-3-1-2-4-15(13)12-5-7-22-8-6-12/h1-4,9-10,12,22H,5-8,11H2
- IUPAC Name
- 4-{2-[(2,4,6-trifluorophenoxy)methyl]phenyl}piperidine
- SMILES
- FC1=CC(F)=C(OCC2=CC=CC=C2C2CCNCC2)C(F)=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 64853713
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Symptomatic Neurogenic Orthostatic Hypotension (NOH) 1 3 Recruiting Treatment Multiple System Atrophy (MSA) / Symptomatic Neurogenic Orthostatic Hypotension (NOH) 1 3 Terminated Treatment MSA / Parkinson's Disease (PD) / Progressive autonomic failure / Symptomatic Neurogenic Orthostatic Hypotension (NOH) 1 3 Terminated Treatment Symptomatic Neurogenic Orthostatic Hypotension (NOH) 1 2 Completed Treatment Attention Deficit Hyperactivity Disorder (ADHD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00146 mg/mL ALOGPS logP 4.13 ALOGPS logP 4.07 Chemaxon logS -5.3 ALOGPS pKa (Strongest Basic) 10.05 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 21.26 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 83.2 m3·mol-1 Chemaxon Polarizability 31.29 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-0309000000-13872a059d44a5cbc1e9 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-00di-0009000000-137c38036737cfccef15 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-0219000000-8f8305c0bb3226165e7b Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0092-0926000000-97aee3b400bc80002d00 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00mo-6692000000-27ec8bbd07ea2f454afa Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-02tc-1390000000-f1a6958cc00795475d5e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 15:18 / Updated at February 21, 2021 18:55