JNJ-26489112
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- JNJ-26489112
- DrugBank Accession Number
- DB15203
- Background
JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 278.71
Monoisotopic: 278.0128057 - Chemical Formula
- C9H11ClN2O4S
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with JNJ-26489112. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with JNJ-26489112. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with JNJ-26489112. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with JNJ-26489112. Alfentanil The risk or severity of CNS depression can be increased when Alfentanil is combined with JNJ-26489112. - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- G1TI012DLT
- CAS number
- 871824-55-4
- InChI Key
- KXSAIQPPGSSNKX-ZETCQYMHSA-N
- InChI
- InChI=1S/C9H11ClN2O4S/c10-6-1-2-8-9(3-6)15-5-7(16-8)4-12-17(11,13)14/h1-3,7,12H,4-5H2,(H2,11,13,14)/t7-/m0/s1
- IUPAC Name
- N-{[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}aminosulfonamide
- SMILES
- NS(=O)(=O)NC[C@H]1COC2=C(O1)C=CC(Cl)=C2
References
- General References
- Not Available
- External Links
- ChemSpider
- 9790860
- BindingDB
- 50444089
- ChEMBL
- CHEMBL3092995
- Wikipedia
- JNJ-26489112
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Photosensitive Epilepsy 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1.9 mg/mL ALOGPS logP 1.31 ALOGPS logP 0.21 Chemaxon logS -2.2 ALOGPS pKa (Strongest Acidic) 10.21 Chemaxon pKa (Strongest Basic) 0.23 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 90.65 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 61.26 m3·mol-1 Chemaxon Polarizability 25.58 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-e478ad15e75e343c9ab6 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-004l-9060000000-f8efee37092c9d17eddf Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004l-9010000000-7ec70b01302a215f5589 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-01si-2890000000-c95a754e9f198304262c Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0059-9100000000-0699e39f08cbef3a4606 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-01r6-9500000000-ab993626f71033390e70 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 14:59 / Updated at June 12, 2020 16:53