Silodrate
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Silodrate
- DrugBank Accession Number
- DB14116
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Structure
- Weight
- Average: 380.832
Monoisotopic: 379.8185655 - Chemical Formula
- Al2H2Mg2O12Si3
- Synonyms
- Magnesium aluminometasilicate
- Silodrate
- Simaldrate
- External IDs
- MP-1051
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Acid indigestion Combination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104) ••• ••• Used in combination to treat Flatulence Combination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104) ••• ••• •••• ••••••••••• Used in combination to treat Flatulence Combination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104) ••• ••• ••••••••• Used in combination to treat Flatulence Combination Product in combination with: Magnesium hydroxide (DB09104), Simethicone (DB09512) ••• ••• •••• ••••••• Used in combination to treat Heartburn Combination Product in combination with: Simethicone (DB09512), Magnesium hydroxide (DB09104) ••• ••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Take separate from meals. Take Inon Ace (dimethicone, magnesium hydroxide, silodrate) between meals,.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Inon Ace Silodrate (200 mg/1) + Dimethicone (20 mg/1) + Magnesium hydroxide (60 mg/1) Tablet Oral Sato Pharmaceutical Co., Ltd. 1995-11-01 Not applicable US Inon Ace Silodrate (900 mg/30mL) + Magnesium hydroxide (250 mg/30mL) Solution Oral Sato Pharmaceutical Co., Ltd. 2000-05-20 Not applicable US
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal oxoanionic compounds
- Sub Class
- Post-transition metal silicates
- Direct Parent
- Post-transition metal silicates
- Alternative Parents
- Miscellaneous silicates / Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides
- Substituents
- Inorganic metalloid salt / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal silicate / Silicate
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9T3UU8T0QK
- CAS number
- 12408-47-8
- InChI Key
- JAUGGEIKQIHSMF-UHFFFAOYSA-N
- InChI
- InChI=1S/2Al.2Mg.3O3Si.H2O.2O/c;;;;3*1-4(2)3;;;/h;;;;;;;1H2;;/q2*+3;2*+2;3*-2;;2*-2
- IUPAC Name
- dialuminium(3+) dimagnesium(2+) tris(oxosilanebis(olate)) hydrate dioxidandiide
- SMILES
- O.[O--].[O--].[Mg++].[Mg++].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O
References
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Oral Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -1.4 Chemaxon pKa (Strongest Acidic) 2.7 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 63.19 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 4.33 m3·mol-1 Chemaxon Polarizability 4.22 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 22, 2018 20:42 / Updated at September 28, 2021 21:54