Phenothiazine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Phenothiazine
- DrugBank Accession Number
- DB11447
- Background
Phenothiazine (PTZ) is an organic thiazine compound.
- Type
- Small Molecule
- Groups
- Experimental, Vet approved
- Structure
- Weight
- Average: 199.27
Monoisotopic: 199.045570468 - Chemical Formula
- C12H9NS
- Synonyms
- 10H-phenothiazine
- dibenzo-1,4-thiazine
- Fenotiazina
- Phenothiazine
- Phenothiazinum
- Thiodiphenylamin
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UAndrogen receptor Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Phenothiazine. Amifampridine The risk or severity of seizure can be increased when Phenothiazine is combined with Amifampridine. Amitriptyline The serum concentration of Nortriptyline, an active metabolite of Amitriptyline, can be decreased when used in combination with Phenothiazine. Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Phenothiazine. Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Phenothiazine. - Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazines
- Sub Class
- Phenothiazines
- Direct Parent
- Phenothiazines
- Alternative Parents
- Diarylthioethers / Benzenoids / 1,4-thiazines / Secondary amines / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Amine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Diarylthioether / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- phenothiazine (CHEBI:37931)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- GS9EX7QNU6
- CAS number
- 92-84-2
- InChI Key
- WJFKNYWRSNBZNX-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H
- IUPAC Name
- 10H-phenothiazine
- SMILES
- N1C2=CC=CC=C2SC2=CC=CC=C12
References
- General References
- Authors unspecified: Phenothiazine. Can J Comp Med Vet Sci. 1940 Dec;4(12):332. [Article]
- Authors unspecified: PHENOTHIAZINE. Bull Am Pharm Assoc. 1946 Jul-Aug;14(7-8):158. [Article]
- Boet DJ: Phenothiazine retinopathy. Ophthalmologica. 1969;158 Suppl:574-82. [Article]
- RAPPAPORT R: [Phenothiazine derivatives]. Fr Med. 1957 Aug-Sep;20(8-9):23-6. [Article]
- Alkemade PP: Phenothiazine-retinopathy. Ophthalmologica. 1968;155(1):70-6. [Article]
- LONGMORE DB: PHENOTHIAZINE PIGMENTATION. Lancet. 1965 Apr 17;1(7390):854. [Article]
- RICHARDS F: PHENOTHIAZINE PIGMENTATION. Lancet. 1965 Aug 28;2(7409):437. [Article]
- Singh SD, Varma A: Phenothiazine poisoning. Indian Pediatr. 1986 Oct;23 Suppl:172-3. [Article]
- McNeill DL: Phenothiazine resistance. Br Med J. 1977 Jul 9;2(6079):127-8. [Article]
- DELGADO JN, COSGROVE FP, ISAACSON EI: PHENOTHIAZINE DERIVATIVES. Tex Med. 1964 Mar;60:315-8. [Article]
- Filip IH, Gal E, Lupan I, Perde-Schrepler M, Lonnecke P, Surducan M, Gaina LI, Hey-Hawkins E, Silaghi-Dumitrescu L: Tuning the coordination properties of phenothiazine by regioselective introduction of diphenylphosphanyl groups. Dalton Trans. 2015 Jan 14;44(2):615-29. doi: 10.1039/c4dt02665a. Epub 2014 Nov 10. [Article]
- Musah RA, Lesiak AD, Maron MJ, Cody RB, Edwards D, Fowble KL, Dane AJ, Long MC: Mechanosensitivity below Ground: Touch-Sensitive Smell-Producing Roots in the Shy Plant Mimosa pudica. Plant Physiol. 2016 Feb;170(2):1075-89. doi: 10.1104/pp.15.01705. Epub 2015 Dec 9. [Article]
- External Links
- KEGG Drug
- D02601
- ChemSpider
- 21106365
- BindingDB
- 50012855
- ChEBI
- 37931
- ChEMBL
- CHEMBL828
- ZINC
- ZINC000100009616
- Wikipedia
- Phenothiazine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.39 mg/mL ALOGPS logP 4.19 ALOGPS logP 3.63 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 17.91 Chemaxon pKa (Strongest Basic) -0.95 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 61.17 m3·mol-1 Chemaxon Polarizability 21.6 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 140.6551771 predictedDarkChem Lite v0.1.0 [M-H]- 145.0318521 predictedDarkChem Lite v0.1.0 [M-H]- 131.44435 predictedDeepCCS 1.0 (2019) [M+H]+ 146.0195251 predictedDarkChem Lite v0.1.0 [M+H]+ 145.5611521 predictedDarkChem Lite v0.1.0 [M+H]+ 134.19081 predictedDeepCCS 1.0 (2019) [M+Na]+ 156.1682865 predictedDarkChem Lite v0.1.0 [M+Na]+ 145.1262521 predictedDarkChem Lite v0.1.0 [M+Na]+ 143.1389 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsAndrogen receptor
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
- Gene Name
- AR
- Uniprot ID
- P10275
- Uniprot Name
- Androgen receptor
- Molecular Weight
- 98987.9 Da
References
- Bisson WH, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R: Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. Epub 2007 Jul 2. [Article]
Drug created at February 25, 2016 18:50 / Updated at February 21, 2021 18:53