Latrunculin B
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Identification
- Generic Name
- Latrunculin B
- DrugBank Accession Number
- DB08080
- Background
Latrunculin B is a 14-membered macrolide attached to 2-thiazolidinone moiety, isolated from Red Sea sponge Latrunculia magnifica.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 395.513
Monoisotopic: 395.176643733 - Chemical Formula
- C20H29NO5S
- Synonyms
- (+)-latrunculin B
- LAT-B
- External IDs
- NSC-339663
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UActin, alpha skeletal muscle Not Available Humans UMKL/myocardin-like protein 1 Not Available Humans UProtein spire homolog 2 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
- Kingdom
- Organic compounds
- Super Class
- Phenylpropanoids and polyketides
- Class
- Macrolides and analogues
- Sub Class
- Not Available
- Direct Parent
- Macrolides and analogues
- Alternative Parents
- Oxanes / Thiazolidines / Enoate esters / Thiocarbamic acid derivatives / Organic carbonic acids and derivatives / Lactones / Hemiacetals / Oxacyclic compounds / Monocarboxylic acids and derivatives / Azacyclic compounds show 5 more
- Substituents
- Aliphatic heteropolycyclic compound / Alpha,beta-unsaturated carboxylic ester / Azacycle / Carbonic acid derivative / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Enoate ester / Hemiacetal / Hydrocarbon derivative show 14 more
- Molecular Framework
- Aliphatic heteropolycyclic compounds
- External Descriptors
- cyclic hemiketal, macrolide, oxabicycloalkane, thiazolidinone (CHEBI:49703)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- LW7U308U7U
- CAS number
- 76343-94-7
- InChI Key
- NSHPHXHGRHSMIK-JRIKCGFMSA-N
- InChI
- InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
- IUPAC Name
- (4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
- SMILES
- [H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/CC\C(C)=C/C(=O)O2)O1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 6436219
- PubChem Substance
- 99444551
- ChemSpider
- 10192733
- ChEBI
- 49703
- ChEMBL
- CHEMBL411879
- ZINC
- ZINC000005751767
- PDBe Ligand
- LAB
- Wikipedia
- Latrunculin
- PDB Entries
- 2q0u / 2v51 / 2v52 / 2yje / 2yjf / 3mn5 / 4b1u / 4b1v / 4b1w / 4b1x … show 16 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0713 mg/mL ALOGPS logP 1.98 ALOGPS logP 3.79 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 11.36 Chemaxon pKa (Strongest Basic) -4.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 84.86 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 105.64 m3·mol-1 Chemaxon Polarizability 42.08 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9326 Blood Brain Barrier - 0.6164 Caco-2 permeable - 0.6528 P-glycoprotein substrate Substrate 0.7551 P-glycoprotein inhibitor I Non-inhibitor 0.9337 P-glycoprotein inhibitor II Non-inhibitor 0.9835 Renal organic cation transporter Non-inhibitor 0.9164 CYP450 2C9 substrate Non-substrate 0.8888 CYP450 2D6 substrate Non-substrate 0.7955 CYP450 3A4 substrate Substrate 0.6295 CYP450 1A2 substrate Non-inhibitor 0.7519 CYP450 2C9 inhibitor Non-inhibitor 0.8065 CYP450 2D6 inhibitor Non-inhibitor 0.9166 CYP450 2C19 inhibitor Non-inhibitor 0.7339 CYP450 3A4 inhibitor Non-inhibitor 0.9353 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8956 Ames test Non AMES toxic 0.6894 Carcinogenicity Non-carcinogens 0.9643 Biodegradation Not ready biodegradable 0.8779 Rat acute toxicity 2.7374 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9832 hERG inhibition (predictor II) Non-inhibitor 0.9064
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0ue9-2592000000-c9f0d689a268c3ff1dae Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-004j-0019000000-775e76ff46c51f2fa803 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0049000000-b384ea43b3471ebbac54 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-004j-0159000000-973a14b972849c707cc9 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-000x-9026000000-a6871f1c10bfd81d0cf5 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0umr-0294000000-a72b255c5e1bf99d3db3 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0f8c-9377000000-61d7e3c41fb50a74bf1e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 194.6729183 predictedDarkChem Lite v0.1.0 [M-H]- 202.56776 predictedDeepCCS 1.0 (2019) [M+H]+ 191.5691183 predictedDarkChem Lite v0.1.0 [M+H]+ 204.46315 predictedDeepCCS 1.0 (2019) [M+Na]+ 192.0162183 predictedDarkChem Lite v0.1.0 [M+Na]+ 210.14783 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsActin, alpha skeletal muscle
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Structural constituent of cytoskeleton
- Specific Function
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Gene Name
- ACTA1
- Uniprot ID
- P68133
- Uniprot Name
- Actin, alpha skeletal muscle
- Molecular Weight
- 42050.67 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
2. DetailsMKL/myocardin-like protein 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transcription regulatory region sequence-specific dna binding
- Specific Function
- Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcription...
- Gene Name
- MKL1
- Uniprot ID
- Q969V6
- Uniprot Name
- MKL/myocardin-like protein 1
- Molecular Weight
- 98917.94 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
3. DetailsProtein spire homolog 2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link ...
- Gene Name
- SPIRE2
- Uniprot ID
- Q8WWL2
- Uniprot Name
- Protein spire homolog 2
- Molecular Weight
- 79669.945 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at September 15, 2010 21:28 / Updated at June 12, 2020 16:52