Anamorelin
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Anamorelin
- DrugBank Accession Number
- DB06645
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 546.716
Monoisotopic: 546.331839236 - Chemical Formula
- C31H42N6O3
- Synonyms
- Anamorelin
- External IDs
- ONO-7643
- RC-1291
- ST-1291
Pharmacology
- Indication
Investigated for use/treatment in cachexia and anorexia.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Anamorelin Hydrochloride 55F75LJQ0V 861998-00-7 VFYAEUWJFGTGGO-GHTUPXNNSA-N
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- Dipeptides
- Alternative Parents
- 3-benzylpiperidines / N-acyl-alpha amino acids and derivatives / Tryptamines and derivatives / Alpha amino acid amides / 3-alkylindoles / Piperidinecarboxamides / N-acylpiperidines / Substituted pyrroles / Benzene and substituted derivatives / Heteroaromatic compounds show 8 more
- Substituents
- 3-alkylindole / 3-benzylpiperidine / 3-piperidinecarboxamide / Alpha-amino acid amide / Alpha-amino acid or derivatives / Alpha-dipeptide / Amine / Amino acid or derivatives / Aromatic heteropolycyclic compound / Azacycle show 27 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- DD5RBA1NKF
- CAS number
- 249921-19-5
- InChI Key
- VQPFSIRUEPQQPP-MXBOTTGLSA-N
- InChI
- InChI=1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1
- IUPAC Name
- 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-(N,N',N'-trimethylhydrazinecarbonyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
- SMILES
- CN(C)N(C)C(=O)[C@@]1(CC2=CC=CC=C2)CCCN(C1)C(=O)[C@@H](CC1=CNC2=CC=CC=C12)NC(=O)C(C)(C)N
References
- General References
- Not Available
- External Links
- ChemSpider
- 8004650
- ChEMBL
- CHEMBL2110579
- ZINC
- ZINC000043130908
- Wikipedia
- Anamorelin
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Cachexia / Non-Small Cell Lung Cancer (NSCLC) 3 3 Completed Treatment Cancer Cachexia (CC) / Non-Small Cell Lung Cancer (NSCLC) 2 2 Active Not Recruiting Supportive Care Advanced Malignant Solid Tumor / C-Reactive Protein Measurement / Cancer Fatigue / Metastatic Malignant Solid Neoplasms / Recurrent Malignant Solid Neoplasm / Weight Loss 1 2 Completed Not Available Cancer Cachexia (CC) 1 2 Completed Treatment Cancer Cachexia (CC) 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0103 mg/mL ALOGPS logP 2.86 ALOGPS logP 2.36 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 12.7 Chemaxon pKa (Strongest Basic) 8.34 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 114.77 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 157.07 m3·mol-1 Chemaxon Polarizability 61.1 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 242.3144167 predictedDarkChem Lite v0.1.0 [M-H]- 222.27121 predictedDeepCCS 1.0 (2019) [M+H]+ 243.6694167 predictedDarkChem Lite v0.1.0 [M+H]+ 224.12335 predictedDeepCCS 1.0 (2019) [M+Na]+ 242.5660167 predictedDarkChem Lite v0.1.0 [M+Na]+ 229.72917 predictedDeepCCS 1.0 (2019)
Drug created at March 19, 2008 16:43 / Updated at February 21, 2021 18:52