RAS GTPase Inhibitors
- Name
- RAS GTPase Inhibitors
- Accession Number
- DBCAT005667
- Description
Drugs that inhibit RAS GTPase.
- Drugs
Drug Drug Description Sotorasib An experimental KRAS inhibitor being investigated for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer. Adagrasib A KRAS inhibitor indicated for the treatment of locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer in patients who have received at least one prior systemic therapy. - Drugs & Drug Targets
Drug Target Type Sotorasib GTPase KRas target Sotorasib Cytochrome P450 3A Subfamily enzyme Sotorasib Cytochrome P450 2C8 enzyme Sotorasib Cytochrome P450 2C9 enzyme Sotorasib Cytochrome P450 2B6 enzyme Sotorasib ATP-binding cassette sub-family G member 2 transporter Sotorasib P-glycoprotein 1 transporter Adagrasib GTPase KRas target Adagrasib Cytochrome P450 3A4 enzyme Adagrasib Cytochrome P450 2C8 enzyme Adagrasib Cytochrome P450 1A2 enzyme Adagrasib Cytochrome P450 2B6 enzyme Adagrasib Cytochrome P450 2C9 enzyme Adagrasib Cytochrome P450 2D6 enzyme Adagrasib P-glycoprotein 1 transporter