Determination of biological activity of adinazolam and its metabolites.
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Sethy VH, Collins RJ, Daniels EG
Determination of biological activity of adinazolam and its metabolites.
J Pharm Pharmacol. 1984 Aug;36(8):546-8.
- PubMed ID
- 6148400 [ View in PubMed]
- Abstract
Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.
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