Fatty acid biosynthesis as a target for novel antibacterials.
Article Details
- CitationCopy to clipboard
Heath RJ, Rock CO
Fatty acid biosynthesis as a target for novel antibacterials.
Curr Opin Investig Drugs. 2004 Feb;5(2):146-53.
- PubMed ID
- 15043388 [ View in PubMed]
- Abstract
The bacterial fatty acid synthesis pathway has significant potential as a target for the development of novel antibacterials. The pathway has been extensively studied in Escherichia coli, the crystal structures of the compounds involved are known and homologous genes are readily identified in the genomes of important pathogens. The currently used drugs triclosan and isoniazid are known to target one step in the pathway. Other experimental compounds such as thiolactomycin and cerulenin effectively inhibit other steps. These known pathway inhibitors are reviewed and the areas for potential future developments are explored.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cerulenin 3-oxoacyl-[acyl-carrier-protein] synthase 1 Protein Escherichia coli (strain K12) YesInhibitorDetails Cerulenin 3-oxoacyl-[acyl-carrier-protein] synthase 2 Protein Escherichia coli (strain K12) YesInhibitorDetails Cerulenin 3-oxoacyl-[acyl-carrier-protein] synthase 3 Protein Escherichia coli (strain K12) YesInhibitorDetails