Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.
Article Details
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Roberge RJ
Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.
J Emerg Med. 2006 Apr;30(3):299-302.
- PubMed ID
- 16677982 [ View in PubMed]
- Abstract
A case of a dystonic reaction is presented that occurred after the use of prochlorperazine, metoclopramide and ondansetron for the treatment of post-operative nausea and vomiting. The onset of dystonia coincided temporally with the removal of a transdermal scopolamine patch used as adjunctive antiemetic therapy. Withdrawal of concurrently administered anticholinergic medication, after recent use of antiemetic medications with dopamine receptor (D2) inhibition, can unmask a dystonic reaction. This case also suggests that transdermal scopolamine may offer an innovative therapy for the treatment of acute dystonic reactions.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Prochlorperazine Dopamine D2 receptor Protein Humans YesAntagonistDetails