Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.
Article Details
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Schjelderup L, Kozlowski MR, Weissman A, Aasen AJ
Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.
Pharm Res. 1988 Apr;5(4):236-7.
- PubMed ID
- 3247303 [ View in PubMed]
- Abstract
The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Oxyphencyclimine Muscarinic acetylcholine receptor M1 Protein Humans YesAntagonistDetails Oxyphencyclimine Muscarinic acetylcholine receptor M2 Protein Humans YesAntagonistDetails Oxyphencyclimine Muscarinic acetylcholine receptor M3 Protein Humans YesAntagonistDetails