Drug interactions with clinafloxacin.
Article Details
- CitationCopy to clipboard
Randinitis EJ, Alvey CW, Koup JR, Rausch G, Abel R, Bron NJ, Hounslow NJ, Vassos AB, Sedman AJ
Drug interactions with clinafloxacin.
Antimicrob Agents Chemother. 2001 Sep;45(9):2543-52.
- PubMed ID
- 11502527 [ View in PubMed]
- Abstract
Many fluoroquinolone antibiotics are inhibitors of cytochrome P450 enzyme systems and may produce potentially important drug interactions when administered with other drugs. Studies were conducted to determine the effect of clinafloxacin on the pharmacokinetics of theophylline, caffeine, warfarin, and phenytoin, as well as the effect of phenytoin on the pharmacokinetics of clinafloxacin. Concomitant administration of 200 or 400 mg of clinafloxacin reduces mean theophylline clearance by approximately 50 and 70%, respectively, and reduces mean caffeine clearance by 84%. (R)-Warfarin concentrations in plasma during clinafloxacin administration are 32% higher and (S)-warfarin concentrations do not change during clinafloxacin treatment. An observed late pharmacodynamic effect was most likely due to gut flora changes. Phenytoin has no effect on clinafloxacin pharmacokinetics, while phenytoin clearance is 15% lower during clinafloxacin administration.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Clinafloxacin Cytochrome P450 1A2 Protein Humans UnknownInhibitorDetails Clinafloxacin Cytochrome P450 2C19 Protein Humans UnknownInhibitorDetails Clinafloxacin Cytochrome P450 2C9 Protein Humans UnknownInhibitorDetails Clinafloxacin Cytochrome P450 2D6 Protein Humans UnknownInhibitorDetails Temafloxacin Cytochrome P450 1A2 Protein Humans UnknownSubstrateInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareFosphenytoinClinafloxacin Clinafloxacin may decrease the excretion rate of Fosphenytoin which could result in a higher serum level. PhenytoinClinafloxacin Clinafloxacin may decrease the excretion rate of Phenytoin which could result in a higher serum level.