Loss of orally administered drugs in GI tract.
Article Details
- CitationCopy to clipboard
Gavhane YN, Yadav AV
Loss of orally administered drugs in GI tract.
Saudi Pharm J. 2012 Oct;20(4):331-44. doi: 10.1016/j.jsps.2012.03.005. Epub 2012 Apr 20.
- PubMed ID
- 23960808 [ View in PubMed]
- Abstract
The aim of this review is to provide a broad perspective on intestinal absorption and the impact of intestinal first-pass metabolism on both clearance and drug-drug interaction prediction along with its historical perspectives. The review also considers abilities to bridge the gap between the increasing amount of intestinal in vitro data and the importance of intestinal first-pass metabolism in vivo. The significance of efflux transporters on the intestinal absorption is also discussed.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Mestranol Cytochrome P450 2C8 Protein Humans NoSubstrateDetails