Drug evaluation: STA-4783--enhancing taxane efficacy by induction of Hsp70.

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Gehrmann M

Drug evaluation: STA-4783--enhancing taxane efficacy by induction of Hsp70.

Curr Opin Investig Drugs. 2006 Jun;7(6):574-80.

PubMed ID
16784029 [ View in PubMed
]
Abstract

The apoptosis stimulator STA-4783 acts by inducing expression of heat shock protein (Hsp)70 on tumor cell surfaces and disrupting the cytoskeletal network. Currently in development by Synta Pharmaceuticals for the potential treatment of solid tumors, phase II clinical trials in non-small-cell lung cancer, melanoma and sarcoma have been initiated.

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