Update on ropinirole in the treatment of Parkinson's disease.

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Shill HA, Stacy M

Update on ropinirole in the treatment of Parkinson's disease.

Neuropsychiatr Dis Treat. 2009;5:33-6. Epub 2009 Apr 8.

PubMed ID

19557097 [ View in PubMed

]

Abstract

Ropinirole is a dopamine agonist, approved for use to treat symptoms of early and advanced Parkinson's disease, is now available in a 24-hour formulation in addition to the immediate release version. This review discusses the mode of action of ropinirole and compares the pharmacokinetics of both formulations. Pivotal studies leading to the approval of both preparations are reviewed in terms of efficacy, dose range and side effects. Patient factors such as compliance are discussed in terms of the place for ropinirole in the armamentarium of Parkinson's disease therapies.

DrugBank Data that Cites this Article

Drugs

Ropinirole

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ropinirole	Alpha adrenergic receptor (Protein Group)	Protein group	Humans	Unknown	Antagonist	Details
Ropinirole	Dopamine D2 receptor	Protein	Humans	Yes	Agonist	Details
Ropinirole	Dopamine D3 receptor	Protein	Humans	Yes	Agonist	Details
Ropinirole	Dopamine D4 receptor	Protein	Humans	Unknown	Agonist	Details

Drug Interactions

Drugs	Interaction
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Ropinirole Diethylstilbestrol	Diethylstilbestrol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Chlorotrianisene	Chlorotrianisene may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Estrone	Estrone may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Dienestrol	Dienestrol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Ethinylestradiol	Ethinylestradiol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.