Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone.
Article Details
- CitationCopy to clipboard
Tauber U, Schroder K, Dusterberg B, Matthes H
Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone.
Eur J Drug Metab Pharmacokinet. 1986 Apr-Jun;11(2):145-9.
- PubMed ID
- 3770015 [ View in PubMed]
- Abstract
The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 micrograms testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56 +/- 2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.83 +/- 3.32%.
DrugBank Data that Cites this Article
- Drugs